ReviewAmerican journal of translational research2024
Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.
Review in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
objectiveEvidence suggests that diethylhexyl phthalate (DEHP) may disrupt thyroid hormone homeostasis by targeting multiple components of the hypothalamic-pituitary-thyroid (HPT) axis, potentially harming human health. However, the relationship between DEHP exposure and thyroid function remains debated. We performed a meta-analysis to clarify the association between DEHP exposure and thyroid function.
methodsWe searched Medline, Embase, the Cochrane Library, and Web of Science for relevant studies that provided quantitative data on the association between DEHP and thyroid hormones. The ROBINS-E tool was used to assess the quality of included studies. Pearson correlation coefficients or regression coefficients (β) with 95% confidence intervals (CIs) were calculated to evaluate the relationship between DEHP exposure and thyroid hormone levels.
resultsTwenty-three studies were included. In adults, thyroxine (TT4) levels (pooled coefficient -0.05, 95% CI [-0.08, -0.03]) and free thyroxine (FT4) levels (pooled coefficient -0.04, 95% CI [-0.06, -0.02]) were negatively associated with urinary DEHP concentration. Additionally, DEHP exposure in adults was positively correlated with thyroid-stimulating hormone (TSH) levels (pooled coefficient 0.03, 95% CI [0.02, 0.04]). In pregnant women, urinary DEHP concentration was negatively correlated with FT4 levels (pooled correlation coefficient -0.04, 95% CI [-0.06, -0.02]). However, no significant association was observed between DEHP exposure and thyroid function in children and adolescents.
conclusionThis meta-analysis demonstrates a significant association between DEHP exposure and serum thyroid hormone levels in adults. However, DEHP exposure appears to have no significant effect on thyroid function in children and adolescents.
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