ArticleAmerican journal of translational research2024
Preemptive hydromorphone analgesia reduces postoperative delirium and stress response in laparoscopic cholecystectomy patients.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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3 authors.
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Abstract
objectiveTo evaluate the effects of preemptive hydromorphone analgesia on postoperative delirium and stress response in patients undergoing laparoscopic cholecystectomy.
methodsA retrospective cohort study was conducted, including 167 patients who underwent laparoscopic cholecystectomy at Xi'an Central Hospital between June 2021 and November 2023. Patients were categorized into an observation group (n=87) receiving preemptive hydromorphone hydrochloride analgesia and a control group (n=80) without preemptive analgesia. Postoperative pain was assessed using the Visual Analogue Scale (VAS), and stress response was evaluated by measuring epinephrine, norepinephrine, and dopamine levels. The incidence of postoperative delirium was recorded. Logistic regression analysis was performed to identify risk factors for postoperative delirium.
resultsThe VAS score at 30 minutes postoperative was significantly lower in the observation group than that in the control group (P<0.001). Similarly, postoperative levels of epinephrine, norepinephrine, and dopamine were significantly reduced in the observation group (all P<0.001). The incidence of postoperative delirium was also significantly lower in the observation group (P<0.05). Multivariate logistic regression analysis identified higher doses of propofol (P<0.001; odds ratio =3.102, 95% confidence interval: 1.144-9.777) and remifentanil (P=0.001; odds ratio =2.376, 95% confidence interval: 1.469-4.290) as independent risk factors for postoperative delirium, indicating a significant increase in delirium risk with higher drug doses.
conclusionPreemptive hydromorphone analgesia significantly alleviates postoperative pain, reduces stress responses, and lowers the incidence of postoperative delirium in patients undergoing laparoscopic cholecystectomy. Compared to conventional analgesia strategies, hydromorphone provides superior pain control and a favorable safety profile.
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