Treatment of Patients With Extraskeletal Ewing Sarcoma in the Scapular and Arm Regions With Wide Resection: A Report of Two Cases and Literature Review.

Extraskeletal Ewing sarcoma (EES) is a rare and aggressive malignancy originating in soft tissues, distinct from osseous Ewing sarcoma. It commonly affects adolescents and young adults but can occur at any age. Due to its rarity and overlapping clinical features with other malignancies, EES poses significant diagnostic and therapeutic challenges. Accurate diagnosis requires a multidisciplinary approach, incorporating imaging, histopathological evaluation, and molecular testing, such as the detection of the EWSR1-FLI1 fusion protein. This case series highlights two instances of EES involving the scapular and arm regions. The clinical presentations, diagnostic workup, and management strategies, including surgery, chemotherapy, and radiotherapy, are detailed. These cases underscore the importance of a collaborative and individualized approach to managing EES. They also contribute valuable insights to the understanding and treatment of this rare malignancy, emphasizing the need for ongoing research and multidisciplinary collaboration in achieving optimal outcomes.