ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Retinal and Choroidal Metrics Are Dynamic Markers of the Maternal Vascular Response to Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Review
- Correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.BMC ophthalmology · 2025Article
- Association between choroidal microvasculature in the eye and Alzheimer's disease risk in cognitively healthy mid-life adults: A pilot study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
12 authors.
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Abstract
introductionWe explored associations between measurements of the ocular choroid microvasculature and Alzheimer's disease (AD) risk.
methodsWe measured the choroidal vasculature appearing in optical coherence tomography (OCT) scans of 69 healthy, mid-life individuals in the PREVENT Dementia cohort. The cohort was prospectively split into low-, medium-, and high-risk groups based on the presence of known risk factors (apolipoprotein E [
resultsChoroidal vasculature was progressively larger between ordinal risk groups, and significantly associated with risk group prediction. DISCUSSIONS: Our results suggest a potential link between the choroidal vasculature and AD risk. However, these exploratory findings should be replicated in a larger sample. Highlights: Ocular choroidal microvasculature is of interest in relation to neurodegeneration due to its autonomic response to systemic, pathophysiological change.Choroidal changes in the prodromal stage of Alzheimer's disease (AD) are unexplored.The PREVENT Dementia cohort offers a unique, non-invasive study of the microvasculature in mid-life individuals at increased risk for developing AD.Significantly increased ocular choroidal vasculature was associated with increased risk (apolipoprotein E carrier and/or family history of dementia) for AD.These exploratory results suggest a potential association between the ocular choroidal vasculature and AD risk. However, findings should be replicated in a larger sample.
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