BDNF expression mediates verbal learning and memory in women in a cohort enriched with risk for Alzheimer's disease.
Kyle J Edmunds, Alyssa A Pandos, Isabella Hoang, Gabriella M Mamlouk, Alice Motovylyak, Sarah R Lose, Sanjay Asthana, Matthew Stremlau, Sterling C Johnson, Henriette van Praag and 1 more
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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1 · What the graph read from it
What it found
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5 · Who and what money
Authors and funding
11 authors.
Kyle J EdmundsWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.ORCID https://orcid.org/0000-0002-6591-4116
Alyssa A PandosWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Isabella HoangWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Gabriella M MamloukWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Alice MotovylyakWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Sarah R LoseWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Sanjay AsthanaWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Matthew StremlauLab of Neurosciences National Institute on Aging (NIA), IRP Baltimore Maryland USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Henriette van PraagLab of Neurosciences National Institute on Aging (NIA), IRP Baltimore Maryland USA.
Ozioma C OkonkwoWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Funding
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk CohortR01AG062167 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2019 to 2023
$4.5M
KLOTHO and Resilience to Synaptic Dysfunction in Preclinical ADR01AG077507 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Ira Frahmand, Ozioma C Okonkwo · 2023 to 2026
$3.1M
Sleep and Aerobic Fitness as Midlife Modifiers of Later Life Cognitive Decline and Alzheimer's Disease Biomarkers in the Wisconsin Sleep CohortR01AG085592 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Ozioma C Okonkwo, PAUL E PEPPARD · 2024 to 2026
$2.3M
Genetic and Lifestyle Determinants of Cognitive Resilience in MidlifeR21AG051858 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2016 to 2017
introductionThis study examined whether sex differences in verbal learning and memory (VLM) are mediated by plasma brain-derived neurotrophic factor (BDNF) expression.
methodsIn a sample of
resultsBDNF partially mediated the sex-VLM relationship (β = -0.07; 95% confidence interval [CI]: -0.18, -0.01). Female DISCUSSION: This study found that circulating BDNF mediates higher verbal memory scores in females-particularly in Highlights: Sex differences in verbal learning and memory (VLM) were mediated by plasma brain-derived neurotrophic factor (BDNF) levels.Women exhibited higher VLM scores and plasma BDNF levels compared to men.The protective effect of BDNF in women was attenuated by apolipoprotein E ε4 carriage.Findings suggest sex-specific mechanisms against verbal memory decline in aging.
Indexed as
Alzheimer's diseaseapolipoprotein E ε4brain‐derived neurotrophic factormemorysexverbal learning
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
BDNF expression mediates verbal learning and memory in women in a cohort enriched with risk for Alzheimer's disease. · full record | OpenQuestion