ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Amyloid-related changes in fluency in patients with subjective cognitive decline.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Diagnostic performance of verbal fluency measures: a cross-sectional study in the stages of cognitive continuum.Alzheimer's research & therapy · 2026Article
- Linguistic Markers in Spontaneous Speech: Insights into Subjective Cognitive Decline (Review).Healthcare (Basel, Switzerland) · 2025Review
- Amyloid-related changes in fluency in patients with subjective cognitive decline.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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9 authors.
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Abstract
introductionWe examined semantic and phonemic fluency in individuals with subjective cognitive decline (SCD) in relation to amyloid status and clinical progression.
methodsA total of 490 individuals with SCD (62 ± 8 years, 42% female, 28% amyloid-positive, 17% clinical progression) completed annual fluency assessments (mean ± SD follow-up 4.3 ± 2.9 years). Associations between fluency trajectories, amyloid status, and clinical progression were examined with linear mixed models and joint models.
resultsAmyloid-positive individuals declined faster than amyloid-negative individuals on semantic fluency ( DISCUSSION: Our results indicate that decline in semantic fluency is an early indicator of cognitive deficits in preclinical Alzheimer's disease. Highlights: Abnormal amyloid burden is associated with decline in semantic fluency.Fluency trajectories are associated with an increased risk of clinical progression.More refined measures are needed to detect the earliest language deficits.
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