Evidence map›Paper›PMID 39822286›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

sTREM2 in discordant CSF Aβ

Danni Li, William G Mantyh, Lu Men, Ishika Jain, Matthew Glittenberg, Binchong An, Lin Zhang, Ling Li, Alzheimer's Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. sTREM2 in discordant CSF AβAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
  3. Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Danni LiDepartment of Lab Medicine and Pathology University of Minnesota Minneapolis USA.
William G MantyhDepartment of Neurology University of Minnesota Minneapolis USA.
Lu MenDepartment of Lab Medicine and Pathology University of Minnesota Minneapolis USA.
Ishika JainDepartment of Lab Medicine and Pathology University of Minnesota Minneapolis USA.
Matthew GlittenbergSchool of Medicine and Public Health University of Wisconsin-Madison Madison USA.
Binchong AnDepartment of Lab Medicine and Pathology University of Minnesota Minneapolis USA.
Lin ZhangSchool of Public Health University of Minnesota Minneapolis USA.
Ling LiDepartment of Experimental and Clinical Pharmacology University of Minnesota Minneapolis USA.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Dementia prevalence, APOE, and blood-based biomarkers of AD in Native American communitiesR01AG080806 · NIA · UNIVERSITY OF MINNESOTA · PI William G Mantyh · 2022 to 2026
$3.7M
Impact of Mitochondrial Lipidomic Dynamics and its Interaction with APOE Isoforms on Brain Aging and Alzheimers DiseaseR01AG081426 · NIA · UNIVERSITY OF MINNESOTA · PI LING LI, Danni Li · 2023 to 2026
$2.6M
Identification of plasma lipoprotein proteins and lipids as biomarkers of innate-immunity and vascular contributions to Alzheimer's disease and Alzheimer's disease-related dementias in older adultsRF1AG079100 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2023 to 2023
$2.2M
Blood Biomarkers as Surrogate Endpoints of Treatment Responses to Aerobic Exercise and/or Cognitive Training in Amnestic Mild Cognitive ImpairmentR01AG059654 · NIA · UNIVERSITY OF MINNESOTA · PI LI, DANNI · 2018 to 2022
$2.2M
NIA NIH HHS R01 AG059654NIA NIH HHS R01 AG080806NIA NIH HHS R01 AG081426NIA NIH HHS RF1 AG079100NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

introductionLittle is known about the factors underpinning discordant cerebrospinal fluid (CSF) amyloid beta (Aβ)

methodsWe stratified 570 non-demented Alzheimer's Disease Neuroimaging Initiative (ADNI) participants by Aβ PET and further by CSF Aβ

resultsRegardless of Aβ PET status, CSF+ DISCUSSION: Our study suggests the potential roles of sTREM2 in discordant CSF Aβ Highlights: 17% of non-demented older adults had discordant CSF Aβ

Indexed as

Alzheimer's disease (AD)amyloid‐β PETCSFAβ42CSFp‐tau/Aβ42CSF sTREM2

Identifiers

PMID39822286
PMCPMC11736621

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.