Evidence map›Paper›PMID 39822213›Full record

ArticleJBMR plus2025

Improvement of bone properties in children with osteogenesis imperfecta after pamidronate: a bone biopsy study.

Delphine Farlay, Mathilde Cornier, Sébastien Rizzo, Valérie Cormier-Daire, Maelle Charpié, Graziella Pinto, Hina Simonnet, Isabelle Badoud, Maude Gerbaix, Pascale Chavassieux and 1 more

Abstract read
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Delphine FarlayINSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.ORCID https://orcid.org/0000-0001-6487-0337
Mathilde CornierINSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.
Sébastien RizzoINSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.
Valérie Cormier-DaireDepartment of Clinical Genetics and Reference Centre for Constitutional Bone Diseases, INSERM U1163, Université de Paris, F-75015 Paris, France.ORCID https://orcid.org/0000-0002-2839-9856
Maelle CharpiéDepartment of Clinical Genetics and Reference Centre for Constitutional Bone Diseases, INSERM U1163, Université de Paris, F-75015 Paris, France.
Graziella PintoDepartment of Pediatric Endocrinology, Necker-Enfants Malades Hospital, F-75015 Paris, France.
Hina SimonnetService de Médecine Physique et de Réadaptation pédiatrique Hôpital Armand-Trousseau, F-75012 Paris, France.
Isabelle BadoudDivision of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospital, CH-1211 Geneva, Switzerland.
Maude GerbaixDivision of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospital, CH-1211 Geneva, Switzerland.
Pascale ChavassieuxINSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.ORCID https://orcid.org/0000-0001-5128-7361
Roland ChapurlatINSERM UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, F-69008 Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OI, or bone brittle disease, is characterized by increased mineralization of bone matrix independently of clinical severity. So, a beneficial effect of antiresorptive treatments such as bisphosphonates (BP) is questionable. We aim to compare the bone matrix characteristics before and after BP pamidronate (PAM). Fifty-eight children (9 ± 5 yr-old) with OI (Type I, III, IV, V, VI, XI, or unknown) received intravenous PAM for 2 yr and underwent transiliac bone biopsies before (

Indexed as

bone mineralizationmineral/collagen propertiesnanoindentationOIpamidronate

Identifiers

PMID39822213
PMCPMC11736749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.