ArticleMicroscopy research and technique2025
Cyto-Genotoxic Assessment of Sulfoxaflor in Allium cepa Root Cells and DNA Docking Studies.
Article in Microscopy research and technique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sulfoxaflor (SFX) is an insecticide that is commonly used for the control of sap-feeding insects. Since SFX is extensively applied globally, it has been implicated in the substantial induction of environmental toxicity. Therefore, in this study, Allium cepa roots have been employed to elucidate the potential cytogenotoxic effects of SFX in non-target cells by examination of mitotic index (MI), chromosomal aberrations (CAs), and DNA damage. Physiological effects of SFX were evaluated by A. cepa root growth inhibition assay, while cytogenotoxic effects were assessed by A. cepa ana-telophase and comet assay. Moreover, DNA binding affinity and binding mode of SFX were examined using molecular docking simulations to shed light on the genotoxic mechanism of action. The half maximal effective concentration (EC
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