Evidence map›Paper›PMID 39821956›Full record

ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2025

Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21.

Ruth C Brown, Allison D'Aguilar, Quinn Hurshman, Rebekah NailorZee, Timothy P York, George Capone, Ananda B Amstadter, Colleen Jackson-Cook

Abstract read
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In one paragraph

Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ruth C BrownDepartment of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0001-8614-1645
Allison D'AguilarDepartment of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
Quinn HurshmanDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Rebekah NailorZeeDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Timothy P YorkDepartment of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
George CaponeKennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-3009-3730
Ananda B AmstadterDepartment of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
Colleen Jackson-CookDepartment of Pathology, Virginia Commonwealth University, Richmond, Virginia, USA.

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Impact of COVID-19 on the Mental Health of People with Down SyndromeK08HD092610 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROWN, RUTH C · 2018 to 2022
$926k
NCATS NIH HHS UL1 TR002649NICHD NIH HHS K08 HD092610NICHD NIH HHS L30 HD103464NIH HHS K08HD092610NIH HHS UL1TR002649
6 · The paper itself

Abstract

People with mosaicism for trisomy 21 have been shown to exhibit many of the same phenotypic traits present in people with non-mosaic Down syndrome, but with varying symptom severity. However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self-report and caregiver-report symptoms of depression and anxiety among a sample of 62 participants with mDS aged 12-46 and assess their association with the percentage of trisomy 21 in blood and/or buccal mucosa cells. The overall MANCOVA revealed a significant effect of trisomy on the set of internalizing scales, controlling for age and gender (p = 0.038, partial eta

Indexed as

Down SyndromeMosaicismAdolescentAdultAnxietyChildDepressionFemaleHumansMaleMiddle AgedPhenotypeSelf ReportYoung Adultanxietydepressionmosaic down syndrometrisomy 21

Identifiers

PMID39821956
PMCPMC12628268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.