Evidence map›Paper›PMID 39821896›Full record

ArticlePediatric dermatology

A Retrospective Review of Oral N-Acetylcysteine for Habit-Driven Cutaneous Disorders.

Diana H Zarowin, Amy Buros Stein, Sarah E Sheppard, James R Treat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Diana H ZarowinAlbert Einstein College of Medicine, Bronx, New York, USA.ORCID https://orcid.org/0000-0002-8431-3666
Amy Buros SteinPediatric Dermatology Research Alliance, Portland, Oregon, USA.
Sarah E SheppardUnit on Vascular Malformations, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
James R TreatSection of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Funding

Cellular and Molecular Mechanisms of Vascular MalformationsZIAHD009003 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SHEPPARD, SARAH · 2022 to 2025
$6.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development ZIA-HD009003-01Intramural NIH HHS ZIA HD009003Pediatric Dermatology Research Alliance
6 · The paper itself

Abstract

Oral N-acetylcysteine (NAC) has shown efficacy for debilitating habit-driven and neuropsychiatric disorders in small, mostly adult studies. We retrospectively evaluated the therapeutic use and safety of oral NAC in 93 children from the Children's Hospital of Philadelphia. This study supports the use of oral NAC for habit-driven skin, hair, and nail abnormalities in pediatric patients.

Indexed as

AcetylcysteineHabitsSkin DiseasesAdministration, OralAdolescentChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTreatment OutcomeAcetylcysteinehair disorderspharmacologypsychocutaneous disordersquality of lifeskin barrier

Identifiers

PMID39821896
PMCPMC12453218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.