Evidence map›Paper›PMID 39821885›Full record

ReviewCurrent nutrition reports2025

Effectiveness of Grape-Based Interventions on Cognitive and Mental Health: Evidence From Human Trials.

Keotshepile Precious Bojang, Manchana Varalakshmi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Keotshepile Precious BojangSchool of Medical Sciences, University of Hyderabad, Hyderabad, Telangana, India.ORCID http://orcid.org/0000-0002-3702-4247
Manchana VaralakshmiSchool of Medical Sciences, University of Hyderabad, Hyderabad, Telangana, India. varamanchana@gmail.com.ORCID http://orcid.org/0000-0001-8072-2414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review evaluates current research on grape-based interventions and their impact on cognitive and mental health. It also explores the putative mechanisms by which the grape-derived compounds might modulate cognitive function. The growing prevalence of cognitive decline and mental health disorders necessitates exploring novel dietary approaches. Grapes, rich in polyphenols, have demonstrated potential benefits in preclinical studies. However, translating these findings to humans remains an ongoing endeavor. RECENT

findingsRecent clinical trials complement existing observational data, suggesting a positive influence of grape consumption on cognition, particularly in areas of memory, learning, and overall cognitive function and emotional well-being. The potential mechanisms involve the antioxidant and anti-inflammatory properties of grapes, which may mitigate neuroinflammation and protect brain cells from free radical damage. Evidence from existing research suggests that grape based interventions may improve cognitive performance through several neuroprotective mechanisms; however, further investigation is needed to understand the protective effects of grape-based interventions on brain function and mental health. Large-scale trials to assess the long-term effects and safety profile of grape interventions are required. Additionally, extensive epidemiological research is needed to confirm the effect of grape interventions on cognitive health and to determine the best beneficial dosage and duration of supplementations to maximise cognitive benefits.

Indexed as

CognitionMental HealthVitisAntioxidantsCognitive DysfunctionFruitHumansNeuroprotective AgentsPolyphenolsAntioxidantsNeuroprotective AgentsPolyphenols

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.