Evidence map›Paper›PMID 39821858›Full record

ArticleMedical oncology (Northwood, London, England)2025

Boric acid impedes glioblastoma growth in a rat model: insights from multi-approach analysis.

Hasan Turkez, Fatih Alper, Cemil Bayram, Cem Baba, Edanur Yıldız, Melik Saracoglu, Muhammed Kucuk, Berrah Gozegir, Metin Kiliclioglu, Mustafa Yeşilyurt and 12 more

Abstract read
In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hasan TurkezDepartment of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Fatih AlperDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Cemil BayramDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.
Cem BabaDepartment of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
Edanur YıldızDepartment of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
Melik SaracogluDepartment of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
Muhammed KucukDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Berrah GozegirDepartment of Pathology, Veterinary Faculty, Atatürk University, Erzurum, Turkey.
Metin KilicliogluDepartment of Pathology, Veterinary Faculty, Atatürk University, Erzurum, Turkey.
Mustafa YeşilyurtDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Ozlem Ozdemir TozluDepartment of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey. ozlem.ozdemir@erzurum.edu.tr.
Ismail BolatDepartment of Pathology, Veterinary Faculty, Atatürk University, Erzurum, Turkey.
Serkan YildirimDepartment of Pathology, Veterinary Faculty, Atatürk University, Erzurum, Turkey.
Muhammed Furkan BarutcigilDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Fatih IsikDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Özlem KikiDepartment of Medical Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Fahri AydınDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Mehmet Enes ArslanDepartment of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
Kenan CadircıDepartment of Internal Medicine, Erzurum Regional Training and Research Hospital, Health Sciences University, Erzurum, Turkey.
Adem KaramanDepartment of Radiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Abdulgani TatarDepartment of Medical Genetics, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Ahmet HacımüftüoğluDepartment of Medical Pharmacology, Medical Faculty, Atatürk University, Erzurum, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited advancements in managing malignant brain tumors have resulted in poor prognoses for glioblastoma (GBM) patients. Standard treatment involves surgery, radiotherapy, and chemotherapy, which lack specificity and damage healthy brain tissue. Boron-containing compounds, such as boric acid (BA), exhibit diverse biological effects, including anticancer properties. This study aimed to examine whether boron supplementation, as BA, can inhibit glioblastoma growth in a xenograft animal model. Using MRI-based tumor size measurement, survival rates, hematological, clinical biochemistry analyses, and genotoxicity parameters, we assessed the impact of BA. Histopathological, immunohistochemical, and immunofluorescence examinations were also conducted. All BA doses (3.25, 6.5, and 13 mg kg

Indexed as

Antineoplastic AgentsBoric AcidsBrain NeoplasmsGlioblastomaAnimalsCell Line, TumorCell ProliferationDisease Models, AnimalHumansMaleRatsXenograft Model Antitumor AssaysAntineoplastic Agentsboric acidBoric AcidsAnticancerBoric acidBoronGlioblastomaXenograft rat model

Identifiers

PMID39821858
PMCPMC11742329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.