Evidence map›Paper›PMID 39821753›Full record

ArticleDrug delivery and translational research2025

Development and in vitro/in vivo evaluation of taste-masked orodispersible films of dapoxetine hydrochloride using ion exchange resins.

Ying Zhou, Peng Yan, Xiangcheng Zhao, Hailong Zhang, Yan Yang, Jinsong Ding

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Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying Zhou *Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China.
Peng Yan *Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China.
Xiangcheng ZhaoXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China.
Hailong ZhangXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China.
Yan YangChangsha Jingyi Pharmaceutical Technology Co., LTD., Changsha, 410006, Hunan, China.
Jinsong DingXiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China. dingjs0221@csu.edu.cn.ORCID 0009-0001-0964-2558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dapoxetine hydrochloride tablets are the most commonly used drug for the treatment of premature ejaculation (PE). However, the tablets must be taken with water 1-3 h before sexual activity, which makes the medication intake conspicuous and inconvenient. This study aimed to develop taste-masked orodispersible films (ODFs) of dapoxetine hydrochloride using ion exchange resins. It was found that the based-Kyron T-134 resin complex achieved a high drug loading of 75.9 ± 1.4%, establishing the mass ratio of dapoxetine hydrochloride to Kyron T-134 at 2:1, and adjusting the solution pH to 5.4 ± 0.05. The effect of pH on the drug loading of the resin was initially characterized by SEM, while the binding mechanism between dapoxetine hydrochloride and the resin was investigated by XRD, DSC, and FTIR. The ODFs exhibited favorable mechanical properties and palatability. Meanwhile, the drug release in both the ODFs and commercially available tablets Priligy

Indexed as

BenzylaminesIon Exchange ResinsNaphthalenesAdministration, OralAdultDrug LiberationHumansHydrogen-Ion ConcentrationMaleTabletsTasteYoung AdultBenzylaminesdapoxetineIon Exchange ResinsNaphthalenesTabletsDapoxetine hydrochlorideIon exchange resinOrodispersible filmsPremature ejaculation

Identifiers

PMID39821753

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.