Evidence map›Paper›PMID 39821751›Full record

ArticleJournal of cancer survivorship : research and practice2026

Depression, non-medical pain prescriptions, and suicidal behavior in cancer survivors.

Judith Mwobobia, Melissa C White, Oyomoare L Osazuwa-Peters, Eric Adjei Boakye, Dina K Abouelella, Justin M Barnes, Chi T Viet, Katherine Ramos, Cheyenne Corbett, Nosayaba Osazuwa-Peters

Abstract read
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Judith MwobobiaBrown School of Social Work, Washington University in St. Louis, St. Louis, MO, USA.
Melissa C WhiteDuke University School of Medicine, Durham, NC, USA.
Oyomoare L Osazuwa-PetersDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA.
Eric Adjei BoakyeDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Dina K AbouelellaDepartment of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, 40 Duke Medicine Circle, Duke South Orange Zone 4212, DUMC 3805, Durham, NC, 27710-4000, USA.
Justin M BarnesDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Chi T VietDepartment of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, USA.
Katherine RamosDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Cheyenne CorbettDuke Cancer Institute, Duke University, Durham, NC, USA.
Nosayaba Osazuwa-PetersDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. nosa.peters@duke.edu.

Funding

HPV, HIV and Oral Microbiota Interplay in Nigerian Youth (HOMINY)R01DE032216 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI MODUPE COKER, Nosayaba Osazuwa-Peters · 2022 to 2026
$4.5M
The REASON Score: An Epigenetic And Clinicopathologic Score to Predict Risk of Poor Survival in Early Stage Oral Squamous Cell Carcinoma PatientsR01DE031395 · NIDCR · LOMA LINDA UNIVERSITY · PI Chi T. Viet · 2022 to 2026
$3.7M
PROSPECT: Premalignant Oral Lesions Pathology and Epigenetic Risk Prediction ToolR01CA293995 · NCI · LOMA LINDA UNIVERSITY · PI AOUIZERAT, BRADLEY E, PEARSON, ALEXANDER THOMAS · 2024 to 2025
$1.4M
Clinical study to evaluate the methylation signature of head and neck squamous cell carcinoma painK23DE030250 · NIDCR · LOMA LINDA UNIVERSITY · PI VIET, CHI T. · 2021 to 2025
$865k
Suicide risk detection and mitigation in patients with head and neck cancerK01DE030916 · NIDCR · DUKE UNIVERSITY · PI OSAZUWA-PETERS, NOSAYABA · 2021 to 2025
$821k
A Patient-Caregiver Behavioral Intervention for Older Adults with Cancer and Mild Cognitive ImpairmentK08CA258947 · NCI · DUKE UNIVERSITY · PI Katherine Ramos · 2022 to 2026
$809k
Long-term Opioid Therapy, Depression and Suicide Mortality Risk in Patients with Head and Neck CancerR21DE032531 · NIDCR · DUKE UNIVERSITY · PI OSAZUWA-PETERS, NOSAYABA · 2022 to 2022
$448k
NCI NIH HHS K08 CA258947NCI NIH HHS R01 CA293995NIDCR NIH HHS K01 DE030916NIDCR NIH HHS K23 DE030250NIDCR NIH HHS R01 DE031395NIDCR NIH HHS R01 DE032216NIDCR NIH HHS R21 DE032531
6 · The paper itself

Abstract

purposeA cancer diagnosis results in significant distress and adverse psychosocial sequelae, including suicide, the 10th leading cause of death in the USA. Primary risks for death by suicide include depression and opioid abuse, which are prevalent among cancer survivors. Yet, it remains unclear whether they are also associated with other suicidal outcomes, such as ideation, planning, and suicidal attempt.

methodsWe used cross-sectional data from the National Survey on Drug Use and Health (2015-2019, N = 214,271), a nationwide study in the USA that provides data on mental health and other health concerns. Outcome of interest was suicidality (suicidal ideation, planning, and attempt). Main exposures were history of depression and non-medical use of pain prescriptions. Using weighted logistic regression analyses adjusted for sociodemographic factors and substance use, we estimated odds of suicidal ideation, planning, and attempt.

resultsThere were 7635 cancer survivors in our study, which was our analytic sample. We found an associations between a history of cancer and suicidal ideation (aOR = 1.32, 95% CI 1.10, 1.58). Among cancer survivors, depression and non-medical use of pain prescriptions were consistently associated with suicidal ideation (aOR

conclusionBoth depression and non-medical pain prescriptions are independently associated with increased odds of suicidal behavior among cancer survivors. Routinely assessing for depression and history of non-medical use of pain prescriptions could be an important suicide prevention strategy in oncology. IMPLICATIONS FOR CANCER SURVIVORS: Given the increased risk of suicide mortality among cancer survivors, it is critical that risk factors for suicidal behavior, such as depression and use of non-medical pain prescriptions, are routinely screened for as part of cancer care.

Indexed as

Cancer SurvivorsDepressionNeoplasmsPainSuicidal IdeationAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedUnited StatesCancer survivorsDepressionNational Survey on Drug Use and Health (NSDUH)Non-medical pain prescriptionsSuicidal behavior

Identifiers

PMID39821751
PMCPMC12217687

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.