Evidence map›Paper›PMID 39821680›Full record

ReviewActa physiologica (Oxford, England)2025

Phosphoproteomics for studying signaling pathways evoked by hormones of the renin-angiotensin system: A source of untapped potential.

Igor Maciel Souza-Silva, Victor Corasolla Carregari, U Muscha Steckelings, Thiago Verano-Braga

Abstract readReview
In one paragraph

Review in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Igor Maciel Souza-SilvaMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0002-6140-3503
Victor Corasolla CarregariLaboratório de Neuroproteômica, Instituto de Biologia, Universidade de Campinas, São Paulo, Brazil.ORCID 0000-0001-6863-1333
U Muscha SteckelingsDepartment of Molecular Medicine, Cardiovascular and Renal Research Unit, University of Southern Denmark, Odense M, Denmark.ORCID 0000-0002-5430-4275
Thiago Verano-BragaDepartment of Molecular Medicine, Cardiovascular and Renal Research Unit, University of Southern Denmark, Odense M, Denmark.ORCID 0000-0002-7083-2588

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309965/2022-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 406936/2023-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.700905/2022-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.916694/2023-00Danmarks Frie Forskningsfond 0134-00297BDanmarks Frie Forskningsfond 4004-00485BFundação de Amparo à Pesquisa do Estado de Minas Gerais BPD-00133-22Novo Nordisk Fonden 0058592Novo Nordisk Fonden 6239
6 · The paper itself

Abstract

The Renin-Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang-(1-9), Ang-(1-7), Ang-(1-5), etc] and Alamandine-related peptides [Ang A, Alamandine, Ala-(1-5)], through intricate enzymatic pathways. Functionally, the RAS is divided into two axes with opposing effects: the classical axis, primarily consisting of Ang II acting through the AT

Indexed as

PhosphoproteinsProteomicsRenin-Angiotensin SystemSignal TransductionAnimalsHumansPhosphoproteinscellular signalingphosphoproteomephosphoproteomicsrenin‐angiotensin system

Identifiers

PMID39821680
PMCPMC11737475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.