Evidence map›Paper›PMID 39821667›Full record

SynthesisPediatric radiology2025

Assessing the safety and effectiveness of endoscopic ultrasound for pediatric hepato-pancreatico-biliary disorders: a systematic review.

Omar Alomari, Khaled A Abualkhair, Khaled Saad, Sara Magdy, Janna A Omran, Mahmoud M AlSanafini, Loay A Hassan, Omar Y ElBasatiny, Djihane Machane, Marwan Abdulrahim and 11 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Omar AlomariUniversity of Health Sciences, Istanbul, Turkey.
Khaled A AbualkhairZagazig University, Zagazig, Egypt.
Khaled SaadAssiut University, Assiut, Egypt. Khaled.ali@med.au.edu.eg.
Sara MagdyAin Shams University, Cairo, Egypt.
Janna A OmranMenoufia University, Menoufia, Egypt.
Mahmoud M AlSanafiniZagazig University, Zagazig, Egypt.
Loay A HassanCairo University, Cairo, Egypt.
Omar Y ElBasatinyCairo University, Cairo, Egypt.
Djihane MachaneFarhat Abbas University, Setif, Algeria.
Marwan AbdulrahimCairo University, Cairo, Egypt.
Hadeer G Abo-ElmagedMenoufia University, Menoufia, Egypt.
Mohamed ElshaiebMinia University, Minia, Egypt.
Mohamed Shawky ElfarargyJouf University, Sakaka, Saudi Arabia.
Amira ElhoufeyAssiut University, Assiut, Egypt.
Hamad Ghaleb DailahJazan University, Jazan, Saudi Arabia.
Aya H SayedAssiut University, Assiut, Egypt.
Alaa IsmailHelwan University, Cairo, Egypt.
Bassel WalidZagazig University, Zagazig, Egypt.
Mahmoud HashemyCairo University, Cairo, Egypt.
Ahmed M AfifiUniversity of Texas MD Anderson Cancer Center, Houston, USA.
Anas ElgenidyCairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic ultrasound (US) has been established as a safe diagnostic tool for adults, but its use in children remains underexplored. The rising prevalence of pediatric hepato-pancreato-biliary disorders requires a closer examination of its utility. In this systematic review, we aimed to evaluate the efficacy, safety, and clinical impact of endoscopic US in the pediatric population, concentrating on its diagnostic accuracy and therapeutic applications.

methodsAll related clinical studies were identified by searching the Web of Science databases, PubMed (MEDLINE), Scopus, Cochrane, and Embase. Data were extracted from relevant studies using a pre-planned Excel sheet.

resultsTwenty-eight studies demonstrated that endoscopic US in children is safe, technically successful, and clinically impactful, offering valuable diagnostic and interventional competencies. Endoscopic US was frequently used for microlithiasis, choledocholithiasis, and pancreaticobiliary anomalies. It reliably outperformed other imaging modalities, effectively reducing the need for more invasive procedures. Endoscopic US had a remarkable clinical impact, with diverse diagnostic yields, highlighting its role in diagnosing and treating children with hepato-pancreato-biliary disorders. The safety profile of endoscopic US in children was excellent, with nominal reported complications.

conclusionOur comprehensive review underlines the promising application of endoscopic US in pediatric hepato-pancreato-biliary diseases. The endoscopic US demonstrates its diagnostic accuracy and therapeutic potential in children, offering a non-invasive, safe, and efficient approach. As we move forward, addressing the identified limitations and expanding the pediatric-specific research on endoscopic US will enhance our ability to provide precise and patient-centered care in managing pediatric hepato-pancreato-biliary disorders.

Indexed as

Biliary Tract DiseasesEndosonographyLiver DiseasesPancreatic DiseasesChildHumansChildComplicationsHepatopancreatobiliary diseasesSafetyUltrasonography, endoscopic

Identifiers

PMID39821667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.