Evidence map›Paper›PMID 39821663›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Can PSMA PET detect intratumour heterogeneity in histological PSMA expression of primary prostate cancer? Analysis of [

Philipp Moritz Adrian Waibel, Ievgen Glavynskyi, Tobias Fechter, Michael Mix, Felix Kind, August Sigle, Cordula Annette Jilg, Christian Gratzke, Martin Werner, Oliver Schilling and 5 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Preclinical evaluation and first-in-human study ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Article
  7. Article
  8. Molecular Imaging in Photon Radiotherapy.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Philipp Moritz Adrian WaibelDepartment of Radiation Oncology, University Medical Centre Freiburg, Robert-Koch Straße 3, 79106, Freiburg, Germany. philipp.waibel@uniklinik-freiburg.de.ORCID 0009-0009-1688-4385
Ievgen GlavynskyiInstitute for Surgical Pathology, University Medical Centre Freiburg, Freiburg, Germany.
Tobias FechterDepartment of Radiation Oncology, University Medical Centre Freiburg, Robert-Koch Straße 3, 79106, Freiburg, Germany.
Michael MixDepartment of Nuclear Medicine, University Medical Centre Freiburg, Freiburg, Germany.
Felix KindDepartment of Nuclear Medicine, University Medical Centre Freiburg, Freiburg, Germany.
August SigleDepartment of Urology, University Medical Centre Freiburg, Freiburg, Germany.
Cordula Annette JilgDepartment of Urology, University Medical Centre Freiburg, Freiburg, Germany.
Christian GratzkeDepartment of Urology, University Medical Centre Freiburg, Freiburg, Germany.
Martin WernerInstitute for Surgical Pathology, University Medical Centre Freiburg, Freiburg, Germany.
Oliver SchillingInstitute for Surgical Pathology, University Medical Centre Freiburg, Freiburg, Germany.
Peter BronsertInstitute for Surgical Pathology, University Medical Centre Freiburg, Freiburg, Germany.
Martin Thomas FreitagDepartment of Nuclear Medicine, University Medical Centre Freiburg, Freiburg, Germany.
Constantinos ZamboglouDepartment of Radiation Oncology, University Medical Centre Freiburg, Robert-Koch Straße 3, 79106, Freiburg, Germany.
Anca-Ligia GrosuDepartment of Radiation Oncology, University Medical Centre Freiburg, Robert-Koch Straße 3, 79106, Freiburg, Germany.
Simon Konrad Benedikt SpohnDepartment of Radiation Oncology, University Medical Centre Freiburg, Robert-Koch Straße 3, 79106, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProstate-specific membrane-antigen positron emission tomography (PSMA PET) is a promising candidate for non-invasive characterization of prostate cancer (PCa). This study evaluated whether PET with tracers [

methodsThirty-five patients with biopsy-proven primary PCa without evidence of metastatic disease nor prior interventions were prospectively enrolled. All patients underwent PSMA PET combined with computer tomography (CT) with either [

resultsThirty-two patients were included in the final analysis. For histological PCa areas, immunohistochemical PSMA expression correlated significantly to SUV

conclusionPSMA PET with both [

Indexed as

Antigens, SurfaceEdetic AcidGene Expression Regulation, NeoplasticGlutamate Carboxypeptidase IIGlycineNiacinamideOligopeptidesPositron-Emission TomographyPositron Emission Tomography Computed TomographyProstatic NeoplasmsAgedFluorine RadioisotopesGallium IsotopesGallium RadioisotopesHumansMaleAntigens, SurfaceEdetic AcidFluorine RadioisotopesFOLH1 protein, humangallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesGlutamate Carboxypeptidase IIGlycineNiacinamideOligopeptidesPSMA-1007PSMA-11HistopathologyIntratumour heterogeneityProstate cancerProstate-specific membrane antigenPSMA PET/CT tracer

Identifiers

PMID39821663
PMCPMC12014795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.