ArticleNeuroradiology2025
Temporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.
Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsTo test utility of diffusion MRI-derived indices in carotid endarterectomy (CEA), change of diffusion tensor imaging (DTI) metrics, cerebral white matter (WM) volumes were evaluated and predictors of overall mortality determined.
methodsProspectively enrolled participants had preoperative, immediate and late postoperative DTI after CEA. WM volumes, DTI metrics (fractional anisotropy, FA; axial, radial, mean diffusivities; AD, RD, MD, respectively) were calculated for the index/contralateral hemispheres at all time points. Temporal changes, predictors of log
results60 subjects (57% male, 69.5 ± 7.2years) were included. Significantly increased AD and MD was observed in both hemispheres comparing the preoperative and immediate postoperative DTI metrics (index AD: β = 0.02 [95%CI:0.01,0.02], p < 0.001; index MD: β = 0.02 [95%CI:0.01,0.03], p < 0.001; contralateral AD: β = 0.01 [95%CI:0.01,0.02], p = 0.001; contralateral MD: β = 0.02 [95%CI:0.01,0.03], p = 0.003). The index MD decreased (β = 0.01 [95%CI:0.01,0.001], p = 0.04), bilateral WM volumes (index WM: β = 0.04 [95%CI:0.02,0.07], p < 0.001; contralateral WM: β = 0.05 [95%CI:0.03,0.07], p < 0.001) decreased significantly between the immediate and late postoperative scans. Postoperative contralateral FA correlated significantly with lower mortality (HR = 0.001 [95%CI:0.001,0.19], p = 0.02); postoperative contralateral RD (HR = 3.74 × 10
conclusionThe increase of various DTI metrics from pre-to-postoperative may be indicative of microstructural deterioration following CEA. Temporal changes between the immediate and late postoperative scans suggest, however, reversal of detrimental WM changes and clearance of presumed subclinical WM edema. Our results also imply, that preserved cerebral properties are protective after CEA.
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