Evidence map›Paper›PMID 39821572›Full record

ArticleJournal of gastrointestinal cancer2025

Prevalence and Risk Factors of Acute Kidney Injury After Colorectal Cancer Surgery.

Ahmed ElSaeed Abdulgalil, Islam H Metwally, Mohammad Zuhdy, Reham Alghandour, Shehab Hasan, Selim Tarabeah, Eman Shahda, Shadi Awny

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Prevalence and risk factors of acute kidney injury in adults with obesity undergoing bariatric surgery: a systematic review and meta-analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed ElSaeed AbdulgalilNephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Islam H MetwallySurgical Oncology Department, Oncology Center Mansoura University (OCMU), Mansoura, Egypt. drislamhany@mans.edu.eg.
Mohammad ZuhdySurgical Oncology Department, Oncology Center Mansoura University (OCMU), Mansoura, Egypt.
Reham AlghandourMedical Oncology Unit, Oncology Center Mansoura University (OCMU), Mansoura, Egypt.
Shehab HasanRoyal Preston Hospital, Preston, UK.
Selim TarabeahFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Eman ShahdaFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Shadi AwnySurgical Oncology Department, Oncology Center Mansoura University (OCMU), Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAcute kidney injury is a sentinel event affecting colorectal cancer patients either as a consequence of surgery or systemic chemotherapy. It is highly correlated with both short and long-term adverse outcomes. This work aimed to study the prevalence, risk factors, and impact on survival of postoperative (PO-AKI) and post-chemotherapy (PC-AKI) after colorectal cancer (CRC) surgery in Egyptian patients.

methodsData of the patients with CRC who underwent surgery over the previous 5 years was retrieved from an internet-based medical system. The incidence of PO-AKI and PC-AKI was calculated, the rate and time to resolution of PO-AKI were recorded, and the possible predictors of AKI were assessed using univariate and multivariate analysis; also, the impact of AKI on patients' survival was tested using survival curves.

resultsFive hundred sixty-one cases fulfilled the inclusion criteria and were included in the study. PO-AKI was detected in 10.5% of the patients. Significant risk factors included intraoperative hypotension, sepsis, hypoalbuminemia, amount of intraoperative bleeding, neoadjuvant therapy, and preoperative chronic kidney disease (CKD). However, only neoadjuvant treatment (hazard ratio (HR) 2.2) and CKD (HR 3.3) maintained significant risk in the multivariate analysis. PC-AKI was observed in 18.7% of the patients treated. Significant risk factors were previous CKD and the chemotherapy type, mainly affecting those who received Irinotecan-based therapy. The hazard ratio was 8.5 and 2.4 respectively, in multivariate analysis. The overall survival was significantly worse in those who developed PO- or PC-AKI (p < 0.001).

conclusionAKI affects more than 25% of CRC patients after surgery and/or chemotherapy. Modifiable risk factors include preoperative hypoalbuminemia, intraoperative bleeding, and/or intraoperative hypotension. While, the more important risk factors were non-modifiable including CKD, neoadjuvant therapy, and Irinotecan-containing regimens. Most kidney injuries are stage I; however, they are associated with shorter overall survival.

Indexed as

Acute Kidney InjuryColorectal NeoplasmsPostoperative ComplicationsAdultAgedEgyptFemaleHumansIncidenceMaleMiddle AgedNeoadjuvant TherapyPrevalenceRetrospective StudiesRisk FactorsAcute kidney injuryColorectal cancerPost-chemotherapy AKIPostoperative AKI

Identifiers

PMID39821572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.