Evidence map›Paper›PMID 39821469›Full record

ArticleMolecular oncology2025

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system.

Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof-de Julio, Christine Peinelt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Temperature and intrinsic CaNature structural & molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Florian BochenInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-1210-980X
Saurav SubediDepartment for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Federico La MannaDepartment for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Sofia JarrinInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Irida PapapostolouInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Marianna Kruithof-de JulioDepartment for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland.
Christine PeineltInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-3474-6893

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030_200380 / 1
6 · The paper itself

Abstract

Transient receptor potential melastatin-4 (TRPM4) ion channel expression is upregulated in prostate cancer (PCa), contributing to increased cell proliferation, migration, adhesion, epithelial-to-mesenchymal transition, cell cycle shift, and alterations of intracellular Ca

Indexed as

Prostatic NeoplasmsSpheroids, CellularTRPM Cation ChannelsAnimalsCell DeathCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMaleNeoplasm MetastasisXenograft Model Antitumor AssaysZebrafishTRPM4 protein, humanTRPM Cation Channelscell deathion channelprostate cancerTRPM4tumor spheroidzebrafish

Identifiers

PMID39821469
PMCPMC12077273

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.