ArticleArchives of gynecology and obstetrics2025
Reproducibility of fetal ultrasound doppler parameters used for growth assessment.
Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Diagnosis of major cardiac defects through routine early pregnancy ultrasound examination.Archives of gynecology and obstetrics · 2026Article
- Antenatal ultrasound diagnosis of fetal micrognathia: validation and reproducibility of quantitative methods.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo produce standards of references for quality control and assess the reproducibility of fetal ultrasound Doppler measurements commonly used for blood flow assessment in fetal growth.
methodsWomen with singleton normal pregnancies were prospectively recruited at University College London Hospital, UK, between 24 and 41 weeks. Umbilical artery (UA), middle cerebral artery (MCA), and their pulsatility indices (PI), resistance indices (RI) and ratios such as cerebro-placental (CPR) and umbilical cerebral ratio (UCR) were obtained twice by two sonographers in training or after completion of training, blind to each other's measurements. Bland-Altman plots were generated, the mean differences and 95% limits of agreement (LOA) were calculated to assess intra- and interobserver reproducibility. Values were expressed as absolute values or as z-score.
resultsOne hundred ten women were recruited. Overall reproducibility was variable for absolute values and highly variable for z-scores, independently from vessel sampled, index or ratio used, intra- or interobserver reproducibility. The widest absolute values of 95% LOA were 0.3 for UA PI, 0.7 for MCA PI, 0.9 for CPR and 0.3 for UCR, respectively. Regarding z-score, the widest 95% LOA were 1.9 for UA PI, 2.1 for CPR and 1 for UCR. Reproducibility was slightly better for intra- compared with interobserver variability. There was significant difference in z-score reproducibility between MCA peak systolic velocity and CPR vs UCR.
conclusionsReference standards of reproducibility of fetal Doppler parameters are produced for standardization and quality-control purposes. Overall, the reproducibility for fetal Doppler parameters was variable independently from vessel sampled, Doppler index (PI or RI) or ratio used, intra- and interobserver comparison. UCR was the most reproducible parameter which should be recommended, together with UA PI, for clinical use and in research studies on fetal growth.
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