Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes.
Xiaofan Jia, Janet M Wenzlau, Caiguo Zhang, Fran Dong, Kathleen Waugh, R David Leslie, Marian J Rewers, Aaron W Michels, Liping Yu, Diabetes Autoimmunity Study in the Young (DAISY) and Autoimmunity Screening for Kids (ASK) Study Group and the Action LADA Consortium
Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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2 · The registry
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5 · Who and what money
Authors and funding
10 authors.
Xiaofan JiaBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.ORCID 0000-0002-2697-0174
Janet M WenzlauBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Caiguo ZhangBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Fran DongBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Kathleen WaughBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
R David LeslieCentre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.ORCID 0000-0002-1786-1531
Marian J RewersBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Aaron W MichelsBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.ORCID 0000-0003-3766-5244
Liping YuBarbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Diabetes Autoimmunity Study in the Young (DAISY) and Autoimmunity Screening for Kids (ASK) Study Group and the Action LADA Consortium
Funding
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
Natural History of Pre-diabetic Autoimmunity (DAISY)R37DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 2001 to 2010
$8.0M
Multiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9M
Molecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3M
Insulin Specific T Cell Response Shaped by Diabetes Protective MHC Class II MoleculesR01DK108868 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS · 2017 to 2026
$3.6M
Autoantibodies targeting deamidated epitopes in insulinoma antigen 2 as biomarkers in T1DR21AI153665 · NIAID · UNIVERSITY OF COLORADO DENVER · PI WENZLAU, JANET MARIE, YU, LIPING · 2021 to 2022
$428k
Autoantigens targeted by CD8 T cells in type 1 diabetes: from islets to bloodR56DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W, NAKAYAMA, MAKI · 2019 to 2019
$194k
MULTIPLE AUTOANTIGENS OF PRETYPE I DMR37DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI EISENBARTH, GEORGE S · 1992 to 1999
article highlightsCD4+ T cells from patients with type 1 diabetes (T1D) have a significant response to post-translationally modified (PTM) deamidated IA-2 peptides; autoantibodies to these PTM neoepitopes remain to be identified in T1D. We aimed to identify autoantibodies specifically targeting reported T-cell reactive, deamidated epitopes of IA-2 and explore their relationship with T1D development. Autoantibodies to deamidated IA-2 were specific to deamidated epitopes and were predominantly present during the late stages of T1D development, challenging the hypothesis that the loss of immune tolerance occurs via post-translational modification of islet antigens. Newly identified autoantibodies to deamidated IA-2 are new biomarkers of islet autoimmunity and have the potential to aid in T1D diagnosis.
Indexed as
AutoantibodiesDiabetes Mellitus, Type 1EpitopesReceptor-Like Protein Tyrosine Phosphatases, Class 8AdolescentAdultAutoantigensCD4-Positive T-LymphocytesChildChild, PreschoolFemaleHumansMaleProtein Processing, Post-TranslationalYoung AdultAutoantibodiesAutoantigensEpitopesReceptor-Like Protein Tyrosine Phosphatases, Class 8
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes. · full record | OpenQuestion