ArticlePloS one2025
The diagnostic accuracy of umbilical cord procalcitonin in predicting early-onset neonatal infection.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Cord blood procalcitonin and soluble urokinase-type plasminogen activator receptor in predicting histological chorioamnionitis - A pilot study.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Early lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.Frontiers in pediatrics · 2026Article
- Trimetallic PtPdCo nanoalloy on hollow porous N-doped carbon fibers: A high-performance electrochemical immunosensor for procalcitonin detection in SIRS diagnosis.Mikrochimica acta · 2025Article
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4 authors.
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Abstract
introductionTo determine the threshold of umbilical cord blood procalcitonin for early-onset neonatal infection diagnosis.
methodThis prospective study was conducted on 126 neonates in the neonatal care unit of Hue University of Medicine and Pharmacy Hospital, Vietnam, from June 01, 2023 to August 31, 2024. All neonates showed signs at birth or risk factors for early-onset infection (EOI) and were divided into two groups: EOI group and non-EOI group. Umbilical cord blood samples were collected for procalcitonin analysis immediately after birth.
resultsThe median procalcitonin (PCT) levels in umbilical cord blood were significantly higher in the EOI group (0.154 ng/ml [0.092-0.197]) compared to the non-EOI group (0.097 ng/ml [0.082-0.134]; p < 0.001). Receiver operating characteristic (ROC) curve determined the optimal threshold value of PCT of 0.142 ng/ml with an AUC 0.751 (95% CI: 0.661-0.841, p<0.001) in the total population. At this cut-off, the Se, Sp, PPV, and NPV were 68.2%, 76.8%, 61.2%, and 81.8%, respectively. The optimal cut-off value for preterm neonates was 0.122 ng/ml (AUC: 0.785, 95% CI: 0.658-0.911, p<0.001) corresponding a Se of 79.2%, Sp of 74.1%, PPV of 73.1%, and NPV of 80.0%. In term group, the optimal cut-off value was 0.150 ng/ml (AUC: 0.726, 95% CI: 0.583-0.860, p<0.01), with a Se of 60.0%, Sp of 80.4%, PPV of 52.2%, and NPV of 84.9%.
conclusionsUmbilical cord blood PCT concentration were elevated in neonates with EOI. PCT could be a valuable marker for the early diagnosis of EOI.
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