Observational studyIndian journal of pediatrics2026
Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) to Platelet Count Ratio in the Prognosis of Neonatal and Pediatric Sepsis.
Observational study in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prognostic Role of NLR and MPV/PLT Ratio in Pediatric Sepsis - Hope or Hype?Indian journal of pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo calculate and assess the role of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV)/ platelet count (PLT) ratios and their trends as prognostic indicators in neonates and children with sepsis.
methodsThis prospective observational study was planned over a period of two years at a tertiary care teaching hospital. Two hundred seventy children with clinical suspicion of or diagnosed as sepsis were enrolled. Serial hemograms (day 1, 4, 7, 10) and trends of NLR and MPV/PLT ratios were reviewed.
resultsNLR on day 10 of hospital stay had maximum sensitivity of 65% and specificity of 62%. Day 1 MPV was significantly higher in the mortality group. There was a significant correlation between lower Pediatric Sequential Organ Failure Assessment (p-SOFA) score and MPV in the survival group. MPV/PLT ratio on day 7 had maximum sensitivity of 85% and specificity of 74% in prediction of mortality. Serial decreasing trend of NLR (2.88-1.16) and MPV/PLT from day 1 to 10 (8.58-8.48) were associated with improved outcome (p < 0.001).
conclusionsHigh NLR, MPV and MPV/PLT on admission are associated with increased mortality in neonatal and pediatric sepsis. Serial decreasing trends in NLR, MPV and MPV/PLT ratio are associated with improved prognosis.
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