Evidence map›Paper›PMID 39821145›Full record

ArticleEye (London, England)2025

Hardy-Rand-Rittler colour vision testing in cone and cone-rod dystrophies: correlation with structural and functional outcome measures.

Brindhan Tharmarajah, Elisa E Cornish, Jonathan Nguyen, Elizabeth Barnes, Kate E Leahy, Anagha Vaze, Robyn V Jamieson, John R Grigg

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In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brindhan TharmarajahSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0009-0003-4485-4008
Elisa E CornishSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-3898-8811
Jonathan NguyenSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Elizabeth BarnesNHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Kate E LeahySave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Anagha VazeSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Robyn V JamiesonSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
John R GriggSave Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. john.grigg@sydney.edu.au.ORCID 0000-0002-6763-8119

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine how Hardy-Rand-Rittler (HRR) colour vision testing correlates with visual functional and structural assessments in Cone and Cone-Rod Dystrophy.

methodsThirty-four Cone and 69 Cone-Rod Dystrophy patients diagnosed by electroretinography (ERG) at the Save Sight Institute in Sydney were included in a retrospective analysis. Each patient's HRR colour vision test scores were compared with markers of cone and rod system function including visual acuity (VA), ERG responses, changes on Spectral Domain Optical Coherence Tomography (OCT) and Fundus Autofluorescence.

resultsThe number of plates identified on HRR testing correlated with logMAR best-corrected distance VA; r(101) = -0.49, p < 0.0001. HRR scores correlated with markers of cone and macula function including OCT Ellipsoid Zone Gap Width, Central Macular and Outer Nuclear Layer Thickness, Full Field ERG 30 Hz flicker amplitudes, light adapted 3.0 b-wave amplitudes and Pattern ERG 15- and 30-degree p50 amplitudes.

conclusionHRR colour vision testing correlates with structural and functional measures in Cone and Cone-Rod Dystrophy. HRR colour vision testing provides a simple clinic-based option to monitor disease changes in Cone and Cone-Rod Dystrophy patients, especially when ERG testing is not available.

Indexed as

Color Perception TestsColor VisionCone DystrophyCone-Rod DystrophiesAdolescentAdultAgedColor Vision DefectsElectroretinographyFemaleHumansMaleMiddle AgedRetinal Cone Photoreceptor CellsRetrospective StudiesTomography, Optical Coherence

Identifiers

PMID39821145
PMCPMC11794465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.