Evidence map›Paper›PMID 39821136›Full record

ArticlePediatric research2025

Pediatric erythromelalgia from multidisciplinary perspectives: a scoping review.

Don Daniel Ocay, Maria Graziano Maloney, Genevieve D'Souza, Catherine A Brownstein, Jacqui Clinch, Dawn Marie Davis, Deirdre De Ranieri, Carolina Donado, Meghan Halpin, Deepa Kattail and 10 more

Abstract readScoping Review
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Don Daniel OcayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. dondaniel.ocay@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-4265-8647
Maria Graziano MaloneyDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Genevieve D'SouzaDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
Catherine A BrownsteinDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Jacqui ClinchDepartment of Pediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, United Kingdom.
Dawn Marie DavisDepartment of Dermatology, Mayo Clinic Rochester, Rochester, MN, USA.
Deirdre De RanieriDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Carolina DonadoDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Meghan HalpinDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Deepa KattailDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children (Sickkids), Toronto, ON, Canada.
Benjamin Howard LeeDepartment of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA.
Kimberly LoboDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Danielle RavettiPatient Partner, Lodi, CA, USA.
Paola SandroniDepartment of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Jennifer N StinsonDepartment of Anesthesia and Pain Medicine, The Hospital for Sick Children (Sickkids), Toronto, ON, Canada.
See Wan ThamDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Gary A WalcoDepartment of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Suellen M WalkerDevelopmental Neurosciences, University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Timothy W YuDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Charles B BerdeDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythromelalgia is a rare, chronic pain disorder characterized by the triad of intense burning sensation, warmth, and redness, primarily involving the hands and feet, and usually alleviated by cold and worsened by heat. The objective of this scoping review was to: 1) map the existing literature on erythromelalgia in youth, 2) identify knowledge gaps, and 3) inform directions for future research in pediatric erythromelalgia. One hundred and sixty-seven studies reporting 411 cases of childhood-onset erythromelalgia were identified. Variability was found in reporting of clinical symptoms, the clinical presentations and diagnostic criteria used for classification of erythromelagia, the clinical assessments and investigations performed, and the types of interventions and management plans utilised. While factors to aid early recognition and optimize management have been identified, there are also significant gaps for future research to address. Ongoing efforts to develop a multicenter registry of pediatric erythromelalgia cases, with standardized data collection and reporting, will be beneficial to establish consensus recommendations for the diagnosis and management of pediatric erythromelalgia. IMPACT: This scoping review maps the existing literature on pediatric erythromelalgia. Variability was found in reporting of clinical symptoms, the clinical presentations and diagnostic criteria used for classification of erythromelagia, the clinical assessments and investigations performed, and the types of interventions and management plans utilised. The development of an international registry would immensely benefit multidisciplinary experts involved in the care of pediatric erythromelalgia and those with lived experience.

Indexed as

ErythromelalgiaAdolescentChildHumans

Identifiers

PMID39821136
PMCPMC12507648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.