Observational studyPediatric research2025
Physiological and behavioral stability of newborns on therapeutic hypothermia for hypoxic-ischemic encephalopathy during parental holding.
Observational study in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Nationwide variability in sedation, analgesia, and developmental care practices during neonatal therapeutic hypothermia: A French national survey.European journal of pediatrics · 2026Article
- Application of the African Philosophy Ubuntu to the Care of Families With Infants Undergoing Therapeutic Hypothermia for the Treatment of Hypoxic-Ischemic Encephalopathy.Nursing philosophy : an international journal for healthcare professionals · 2026Article
- EDIN and N-PASS pain scale comparison in asphyxiated newborns treated with therapeutic hypothermia.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
Corrections and comments
- Commented on by
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysical separation contributes to parental trauma and poor bonding in the context of therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Parental holding (PH) may improve parents' experience. We aim to determine the physiological and behavioral stability of the newborn held by the parents during TH.
methodsObservational, prospective, single-center study which included 30 newborns with mean gestational age of 39 (1.8) weeks and mean birth weight 3165 (508) g, with HIE treated by TH, whom parents wanted to hold. All infants were mechanically ventilated and received sedation-analgesia. Main outcome was change in body temperature (> 34°C or < 33 °C) during PH. Secondary outcomes were change in vital signs and behavior (comfort/pain scores) during PH. Parental and nurses' opinions were assessed by a self-reporting questionnaire with a 10-point Likert scale.
resultsWe found no significant changes in temperature, other vital signs or in infants' COMFORT-B score during parental holding. Responses to self-reporting questionnaires completed by parents and nurses showed a high level of overall effectiveness and satisfaction with PH.
conclusionParents holding newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy was safe for the newborn without causing discomfort. It was also beneficial for the parents and supported by the healthcare team. IMPACT: Parents holding newborns undergoing therapeutic hypothermia for Hypoxic Ischemic Encephalopathy was feasible without causing discomfort. It was also beneficial for the parents and supported by the healthcare team. Infants' temperature or other vital signs did not change during parental holding, which was found very satisfactory by parents and healthcare givers, showing that parental holding is feasible. This study promotes further dissemination of parental holding, which may limit the detrimental effect of physical separation for parents of newborns undergoing therapeutic hypothermia.
Indexed as
Identifiers
39821131What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.