ArticleJournal of the National Cancer Institute2025
Incidence and prognostic implications of prostate-specific antigen persistence and relapse after radical prostatectomy: population-based study.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Estimation and Prognostic Role of Prostate-specific Antigen (PSA) Doubling Time After Radical Prostatectomy.European urology open science · 2026Article
- Incidence and prognostic implications of PSA relapse after radical radiotherapy for prostate cancer: a population-based study.BJU international · 2026Article
- Enhanced nodal staging by molecular detection of KLK3, FOLH1, and PCA3 in prostate cancer.Discover oncology · 2026Article
- Emerging role of low-frequency somatic mutations in cancer relapse: from early detection to precision oncology.Frontiers in oncology · 2026Review
- Postprostatectomy prostate cancer treated with radiation therapy: adverse features and androgen deprivation therapy use in a statewide consortium.JNCI cancer spectrum · 2025Article
- Cohort Profile Update: The National Prostate Cancer Register of Sweden and PCBase.International journal of epidemiology · 2025Article
- Detectable prostate-specific antigen after radiotherapy for clinically localized prostate cancer.Cancer · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThere has been a wide range in incidence of prostate-specific antigen (PSA) persistence and relapse after radical prostatectomy (RP) for prostate cancer (PCa). We aimed to describe incidence and prognostic implications of PSA persistence and relapse.
methodsRegister-based cohort study in Sweden of men diagnosed with PCa between 2007 and 2020 who underwent RP. Risks were estimated using competing risk cumulative incidence curves. Treatment after persistence or relapse and risk of PCa death and other causes were stratified according to persistence, European Association of Urology relapse risk groups, time to relapse, and life expectancy based on age and comorbidities.
resultsAmong 10 700 men, the 10-year risk of PSA persistence or relapse after RP was 34% (95% confidence interval = 32% to 35%). Within 12 months of persistence/relapse, 75% of men with persistence, high-risk relapse, or early relapse (<2 years) received treatment. The 10-year risk of PCa death ranged from 12% for men with persistence to 2% in men with low-risk relapse, whereas death from other causes ranged from 11% to 16%. Risk of PCa death was 8.5% after early relapse (<2 years) and 1.4% after late relapse (>5 years).
conclusionsThis population-based study estimated that one-third of men would have PSA persistence or relapse within 10 years from RP. There was a wide range in risk of death from PCa according to cancer characteristics and time to relapse. Risk of death from other causes was substantial. These factors, along with life expectancy, should inform treatment decisions for men with persistence or relapse.
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