ArticleAnnals of intensive care2025
Critically ill adult patients with acute leukemia: a systematic review and meta-analysis.
Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Temporal trends and prognostic factors in critically ill adult patients with acute leukemia: an individual participant data meta-analysis.Intensive care medicine · 2026Pooled it
- Early mortality in patients with acute promyelocytic leukemia: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Beyond classical boundaries: rethinking ICU access in acute leukemia.Intensive care medicine · 2026Article
- Impact of immunosuppression on the incidence of ventilator-associated events: an observational study.BMC anesthesiology · 2026Observational
- Dynamic changes in mortality risk factors for acute leukemia patients in the ICU and Post-ICU periods.Annals of hematology · 2026Article
- Short-term mortality after intensive care admission in acute lymphoblastic versus predominantly acute myeloid leukemia: a retrospective cohort study using MIMIC-IV with eICU external replication.Frontiers in oncology · 2026Article
- Factors associated with treatment resumption and long-term outcomes after ICU discharge in patients with hematological malignancies.Annals of intensive care · 2026Article
- Novel insights and clinical perception of the patients with acute leukemia transferred to ICU: a multi-center retrospective study spanning 10 years.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe the use of life-sustaining therapies and mortality in patients with acute leukemia admitted to the intensive care unit (ICU).
methodsThe PubMed database was searched from January 1st, 2000 to July 1st, 2023. All studies including adult critically ill patients with acute leukemia were included. Two reviewers independently selected the studies, assessed bias using the Newcastle-Ottawa scale for cohort studies, and performed data extraction from full-text reading. We performed a proportional meta-analysis using a random effects model. The primary outcome was all-cause ICU mortality. Secondary outcomes included reasons for ICU admission, use of organ support therapies (mechanical ventilation, vasopressors and renal replacement therapy), hospital, day-90 and one-year mortality rates.
resultsOf the 1,331 studies screened, 136 (24,861 patients) met the inclusion criteria and were included in the meta-analysis. Acute myeloid leukemia affected 16,269 (66%) patients, acute lymphoblastic leukemia affected 835 (3%) patients, and the type of leukemia was not specified in 7,757 (31%) patients. Acute respiratory failure (70%) and acute circulatory failure (25%) were the main reasons for ICU admission. Invasive mechanical ventilation, vasopressors and renal replacement therapy, were needed in 65%, 53%, and 23% of the patients, respectively. ICU mortality was available in 51 studies (6,668 patients, of whom 2,956 died throughout their ICU stay), resulting in a metanalytical proportion of 52% (95% CI [47%; 57%]; I
conclusionAcute respiratory failure is the main reason for ICU admission in patients with acute leukemia. Mechanical ventilation is the first life-sustaining therapy to be used, and also a strong predictor of mortality.
trial registrationThis study's protocol was preregistered on PROSPERO (CRD42023439630).
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