SynthesisMetabolic brain disease2025
Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review.
Synthesis in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tai chi in mental health interventions: a narrative review comparing its role with pharmacotherapy and psychotherapy.Frontiers in psychology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance use disorders (SUDs) pose a significant global health challenge, with relapse being a major obstacle in achieving successful treatment outcomes. In recent years, drug delivery strategies have emerged as promising tools to improve treatment efficacy and patient compliance in the context of SUD. Here we explore a diverse range of drug delivery strategies that have been investigated for addressing relapse behavior in SUD. By examining a wide array of clinical and preclinical studies, this review highlights the advances made in drug delivery technologies in the hopes of aiding future research to further establish novel systems. The present systematic review has been created after gathering data from multiple databases including Google Scholar, PubMed and Cochrane, taking into account both review and research (preclinical and clinical) studies along with other systematic reviews and meta-analyses. Relevant articles have been categorized into those pertaining to opioid use disorder, alcohol use disorder and tobacco use disorder. Substance use disorders are a global health problem, with tobacco use associated with the highest mortality, followed by alcohol and opioids. Conventional drug delivery options, such as oral medication have a number of disadvantages, such as low compliance. To tackle these challenges, multiple novel strategies such as sustained release implants, transdermal patches and liquid crystal-based injections have been developed. This systematic review presents a concise view of the strategies already available, as well as those currently undergoing trials. By doing so, the authors hope to stimulate further research to help overcome the challenges in treating SUDs.
Indexed as
Identifiers
39820990What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.