ArticlePloS one2025
Deep learning-based skin lesion analysis using hybrid ResUNet++ and modified AlexNet-Random Forest for enhanced segmentation and classification.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Artificial intelligence with deep learning driven entropy-curvature attention mechanism for detection and segmentation of skin lesions using biomedical images.Scientific reports · 2026Article
- An Optimal Deep Hybrid Framework with Selective Kernel U-Net for Skin Lesion Detection and Classification.Bioengineering (Basel, Switzerland) · 2026Article
- An Improved Capsule Network for Image Classification Using Multi-Scale Feature Extraction.Journal of imaging · 2025Article
- H-fusion SEG: dual-branch hyper-attention fusion network with SAM integration for robust skin disease segmentation.Scientific reports · 2025Article
- Multiclass skin lesion classification and localziation from dermoscopic images using a novel network-level fused deep architecture and explainable artificial intelligence.BMC medical informatics and decision making · 2025Article
- Enhanced Multi-Class Breast Cancer Classification from Whole-Slide Histopathology Images Using a Proposed Deep Learning Model.Diagnostics (Basel, Switzerland) · 2025Article
- Skin disease diagnosis using decision and feature level fusion of deep features.Frontiers in digital health · 2025Article
- Skin-lesion segmentation using boundary-aware segmentation network and classification based on a mixture of convolutional and transformer neural networks.Frontiers in medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
Skin cancer is considered globally as the most fatal disease. Most likely all the patients who received wrong diagnosis and low-quality treatment die early. Though if it is detected in the early stages the patient has fairly good chance and the aforementioned diseases can be cured. Consequently, diagnostic identification and management of the patient at this level becomes a rather enormous task. This paper offers a cutting-edge hybrid deep learning approach of better segmentation and classification of skin lesions. The proposed method incorporates three key stages: preprocessing, segmentation of lesions, and classification of lesions. By the stage of preprocessing, a morphology-based technique takes out hair so as to enhance the segmentation precision to use the cleansed images for subsequent analysis. Segmentation cuts off the lesion from the surrounding skin, giving the classification phase a dedicated area of interest and the ability to clear the background noise that may affect classification rates. The isolation enables the model to better analyze anatomical lesion features in order to achieve accurate benign and malignant classifications. Using ResUNet++, the cutting-edge deep learning architecture, we achieved accurate lesion segmentation. Next, we will modify and use an AlexNet-Random Forest (AlexNet-RF) based classifier for robust lesion classification. The proposed hybrid deep learning model is intensively validated on the Ham10000 data set which is one of the most popular datasets for skin lesions analysis. The obtained results show that the utilized approach, compared to the previous ones, is more effective, giving better segmentation and classification results. This method takes advantage of ResUNet++ strong classification skill and modified AlexNet-Random Forest robustness for more accurate segmentation. There is a high probability that ResUNet++, which is highly proficient at medical image segmentation, can produce better segmentation of lesions than the simpler models. The composition of AlexNet's extraction of features with Random Forest ability to reduce overfitting possibly may be more precise in the classification when compared to using only one model.
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