Evidence map›Paper›PMID 39820675›Full record

ArticleAnalytical and bioanalytical chemistry2025

A "hand-held" polarimeter for on-site chiral drug measurement and chemical reaction monitoring.

Rui Huang, Zhexuan Lin, Yanting Liu, Xuewan Wu, Kaisong Yuan

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui HuangBio-analytical Laboratory, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, China.
Zhexuan LinBio-analytical Laboratory, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, China.
Yanting LiuBio-analytical Laboratory, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, China.
Xuewan WuBio-analytical Laboratory, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, China.
Kaisong YuanBio-analytical Laboratory, Shantou University Medical College, No. 22, Xinling Road, Shantou, 515041, China. ksyuan@stu.edu.cn.ORCID http://orcid.org/0000-0003-3978-0908

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515010611Guangdong Basic and Applied Basic Research Foundation 2024A1515010890Innovative Young Talents Grant of Guangdong Department of Education 2022KQNCX020National Natural Science Foundation of China 22204095SUMC Scientific Research Initiation Grant 510858045
6 · The paper itself

Abstract

A polarimeter is a common but critical instrument for measuring the optical rotation of chiral compounds, ranging from the pharmaceutical to chemical industry, or even employed in monitoring chemical reactions for research purposes. Developing a portable polarimeter helps to transfer the measurements from the laboratory to on-site detection. Herein, we design a new portable polarimeter with a "hand-held" scale. Technically, we innovatively adopted a rotary potentiometer coupled with a high-precision voltmeter to signify the angle changes after polarized light travels through the chiral compound solution. Compared with the commercial disc polarimeter that uses a dial to measure the optical rotation, such a design shows superiority in being easy to read. This "hand-held" polarimeter meets the high demand for on-site detection on the premise of low cost. Bland-Altman analysis results showed consistency between our device's optical rotation detection method and the commercial disc polarimeter. The "hand-held" polarimeter can measure the optical rotation of a chiral drug and be applicable to monitor the progress of a chemical reaction. As such, this "hand-held" polarimeter shows great potential to assist scientists in scientific research, or for on-site measurement with high portability.

Indexed as

Equipment DesignPharmaceutical PreparationsOptical RotationStereoisomerismPharmaceutical PreparationsChemical reaction monitoringChiral drugOn-site measurementPolarimetryRotary potentiometer

Identifiers

PMID39820675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.