Evidence map›Paper›PMID 39820658›Full record

Observational studyPediatric surgery international2025

Postnatal management of preterm infants with congenital diaphragmatic hernia.

Emma E Williams, Stephanie Lau, Nimrah Abbasi, Eveline Lapidus-Krol, Priscilla P L Chiu, Brian T Kalish

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emma E WilliamsDivision of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
Stephanie LauDepartment of Paediatrics, University of Toronto, Toronto, ON, Canada.
Nimrah AbbasiMaternal Fetal Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Eveline Lapidus-KrolDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada.
Priscilla P L ChiuDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada.
Brian T KalishDivision of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada. brian.kalish@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCongenital diaphragmatic hernia (CDH) in the preterm population is increasingly common in the current era of fetal endoluminal tracheal occlusion (FETO) therapy. There remains a lack of clinical guidance for clinicians and surgeons regarding optimal management strategies for such infants. We aimed to describe our experience in managing preterm CDH in a single quaternary neonatal intensive care unit (NICU).

methodsThis was a retrospective single-center observational case series of preterm infants born between 2017 and 2024 at less than 37 weeks of gestation and diagnosed with CDH (pre- or post-natally).

resultsThirty-two infants with a median (range) gestational age of 33.9 (27.0-36.9) weeks and a birth weight of 1975 (1070-3290) grams. Twenty-two infants (68.8%) were diagnosed with CDH prenatally and 43.8% underwent antenatal FETO. The median time of surgical repair was at 10 (2-47) days of life. The duration of invasive mechanical ventilation was 11 (1-115) days. Nineteen infants (59.4%) survived to discharge with a median postmenstrual age at time of discharge of 40.6 (36.0-51.0) weeks. Two infants developed a grade 3 or 4 intraventricular hemorrhage. Five infants required home oxygen at discharge.

conclusionPreterm CDH confers high morbidity and mortality. Robust clinical evidence, multicenter studies and standardized guidelines are needed to improve outcomes in this challenging patient population.

Indexed as

Hernias, Diaphragmatic, CongenitalInfant, Premature, DiseasesFemaleGestational AgeHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleRespiration, ArtificialRetrospective StudiesCongenital diaphragmatic herniaLung hypoplasiaMechanical ventilationPrematurityPulmonary hypertension

Identifiers

PMID39820658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.