Evidence map›Paper›PMID 39820605›Full record

ArticleNature structural & molecular biology2025

Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage.

Shiqi Zhu, Peng Xie, Yi Yang, Yan Wang, Chuanxin Zhang, Yu Zhang, Shuhan Si, Jin Zhang, Jingjing He, Hao Si and 29 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. [Stem cell therapy for premature ovarian insufficiency: a review of clinical evidence and therapeutic strategies].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Shiqi Zhu *Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Peng Xie *School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Yi Yang *Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Yan Wang *Department of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Chuanxin Zhang *Center of Reproductive Medicine, Shandong University, Jinan, China.
Yu Zhang *College of Animal Sciences, Zhejiang University, Hangzhou, China.
Shuhan SiKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Jin ZhangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Jingjing HeKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Hao SiKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Ke FangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Binbin MaSchool of Life Science and Technology, Tongji University, Shanghai, China.
Xu JiangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Lindi HuangKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Jiamin LiKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Tian MinKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Beihong ZhengCenter of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Fujuan, China.
Lincui DaCenter of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Fujuan, China.
Dianliang LinCenter of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Fujuan, China.
Kun GaoKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.
Yuanyuan LiSchool of Life Science and Technology, Tongji University, Shanghai, China.
Mingtao HuangDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Fengchang QiaoDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Haiqin HuoDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Haoyang FengDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Han ZhaoCenter of Reproductive Medicine, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-9515-7534
Zijiang ChenCenter of Reproductive Medicine, Shandong University, Jinan, China.ORCID http://orcid.org/0000-0001-6637-6631
Zhengfeng XuDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China.
Jing XieSchool of Life Science and Technology, Tongji University, Shanghai, China.
Hua CaoCenter of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Fujuan, China.
Jin LiuSchool of Data Science, The Chinese University of Hong Kong, Shenzhen, China.ORCID http://orcid.org/0000-0002-5707-2078
Xuebiao YaoLaboratory for Organelle Dynamics and Plasticity Control, School of Life Sciences, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0001-8982-5911
Wei XieKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.ORCID http://orcid.org/0000-0002-9179-4787
Yan SunCenter of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Fujuan, China. sunyan62@163.com.ORCID http://orcid.org/0000-0002-6909-6018
Keliang WuCenter of Reproductive Medicine, Shandong University, Jinan, China. wukeliang_527@163.com.ORCID http://orcid.org/0000-0001-9552-6096
Bo XiongCollege of Animal Sciences, Zhejiang University, Hangzhou, China. xiongbo@zju.edu.cn.ORCID http://orcid.org/0000-0003-2456-4559
Ping HuDepartment of Prenatal Diagnosis, Women's Hospital of Nanjing Medical University, Nanjing, China. njfybjyhuping@163.com.ORCID http://orcid.org/0000-0002-7297-8847
Zhuojuan LuoKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China. zjluo@seu.edu.cn.ORCID http://orcid.org/0000-0002-0715-0648
Chengqi LinKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China. cqlin@seu.edu.cn.ORCID http://orcid.org/0000-0002-2121-584X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to an estimated 10% of women experience miscarriage in their lifetimes. Embryonic aneuploidy is a leading cause for miscarriage, infertility and congenital defects. Here we identify variants of ELL3, a gene encoding a transcription elongation factor, in couples who experienced consecutive early miscarriages due to embryonic aneuploidy. Maternal ELL3 knockout leads to mouse oocyte aneuploidy, subfertility and miscellaneous embryonic defects. Mechanistically, we find that ELL3 localizes to the spindle during meiosis, and that ELL3 depletion in both mouse and human oocytes increases the incidence of meiotic spindle abnormality. ELL3 coordinates with TPX2 to ensure the proper function of the microtubule motor KIF11. Live imaging analysis shows that ELL3 is paramount for promoting spindle assembly and driving chromosome movement. Together, our findings implicate maternal ELL3 deficiency in causing oocyte aneuploidy and early miscarriage.

Indexed as

Abortion, SpontaneousAneuploidyOocytesAnimalsCell Cycle ProteinsFemaleHumansKinesinsLoss of Function MutationMaleMeiosisMiceMice, KnockoutMicrotubule-Associated ProteinsPregnancySpindle ApparatusCell Cycle ProteinsKinesinsMicrotubule-Associated Proteins

Identifiers

PMID39820605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.