Evidence map›Paper›PMID 39820429›Full record

ArticleAnnals of hematology2025

Topological importance of CD8

Hiromichi Takahashi, Shun Ito, Yoko Nakanishi, Katsuhiro Miura, Haruna Nishimaki, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hiromichi Takahashi *Department of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Shun Ito *Department of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Yoko NakanishiDepartment of Pathology and Microbiology Division of Oncologic Pathology, Nihon University School of Medicine, Tokyo, Japan.
Katsuhiro MiuraDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan. miura.katsuhiro@nihon-u.ac.jp.ORCID http://orcid.org/0000-0002-1538-3804
Haruna NishimakiDepartment of Pathology and Microbiology Division of Oncologic Pathology, Nihon University School of Medicine, Tokyo, Japan.
Masaru NakagawaDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Shimon OtakeDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Takashi HamadaDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Takashi KoikeDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Kazuhide IizukaDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.
Shinobu MasudaDepartment of Pathology and Microbiology Division of Oncologic Pathology, Nihon University School of Medicine, Tokyo, Japan.
Tomohiro NakayamaDepartment of Pathology and Microbiology Division of Laboratory Medicine, Nihon University School of Medicine, Tokyo, Japan.
Tetsuo ShimizuDepartment of Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan.
Naoya IshibashiDepartment of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Hirofumi KogureDepartment of Medicine Division of Gastroenterology and Hepatology, Nihon University School of Medicine, Tokyo, Japan.
Hideki NakamuraDepartment of Medicine Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan.

Funding

JSPS KAKENHI JP20K16397
6 · The paper itself

Abstract

Classic Hodgkin lymphoma (CHL) histologically consists of Hodgkin Reed-Sternberg (HRS) cells and the tumor microenvironment (TME), but the relationship between TME characteristics and clinical features of CHL remains unclear. We aimed to investigate the effects of the TME structure on the outcomes of patients with CHL. We performed a high-throughput analysis of HRS cells and their topological relationship with the reactive immune cells in the TME. After multiplexed immunofluorescence labeling against CD4, CD8, CD30, CD68, CD163, PD-1, and PD-L1, visual images were analyzed. Phenotypes were assigned to all reactive cells, such as CD4

Indexed as

CD8-Positive T-LymphocytesHodgkin DiseaseTumor MicroenvironmentAdolescentAdultAgedFemaleHumansMacrophagesMaleMiddle AgedReed-Sternberg CellsYoung AdultCD8+ T-cellClassic Hodgkin lymphomaHodgkin Reed-Sternberg cellMultiplexed immunofluorescenceTumor microenvironment

Identifiers

PMID39820429
PMCPMC11971151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.