Evidence map›Paper›PMID 39820414›Full record

ArticleJournal of burn care & research : official publication of the American Burn Association2025

Cytokine Storm in a Massively Burned Pediatric Patient.

Mala Sharma, Lauren Roach, Ashleigh Bull, LeeAnne Flygt, Zuhair Ballas, Alex Kurjatko, Madhuradhar Chegondi, Lucy Wibbenmeyer

Abstract readCase Reports
In one paragraph

Article in Journal of burn care & research : official publication of the American Burn Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mala SharmaDivision of Acute Care Surgery, Department of Surgery, University of Iowa, Iowa City, IA, United States.ORCID 0009-0000-3722-0494
Lauren RoachDivision of Critical Care, Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, United States.
Ashleigh BullDivision of Acute Care Surgery, Department of Surgery, University of Iowa, Iowa City, IA, United States.ORCID 0009-0002-0888-1976
LeeAnne FlygtDivision of Critical Care, Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, United States.
Zuhair BallasImmunology Division, Department of Internal Medicine, Carver College of Medicine, University of Iowa and the Iowa City VA, Iowa City, IA, United States.ORCID 0000-0001-5569-1230
Alex KurjatkoDivision of Acute Care Surgery, Department of Surgery, University of Iowa, Iowa City, IA, United States.
Madhuradhar ChegondiDivision of Critical Care, Department of Pediatrics, University of Illinois College of Medicine, Peoria, IL, United States.ORCID 0000-0002-1375-6988
Lucy WibbenmeyerDivision of Acute Care Surgery, Department of Surgery, University of Iowa, Iowa City, IA, United States.ORCID 0000-0003-1424-069X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokine storm can occur in many different clinical conditions and lack of recognition can lead to death. While cytokines have been measured and trended in burn patients, cytokine storm has not been widely discussed or its treatment reported. We present herein the diagnosis and the treatment of a 5-year-old, 91% burn patient, who developed cytokine storm 3 times during his hospital course. Aggressive treatment led to a successful resolution. Cytokine storm should be entertained in patients who develop classic storm signs and symptoms, along with supporting laboratory. Treatment should be tailored to the patients' clinical picture. More study is warranted to define cytokine storm as well as its treatment in burn patients.

Indexed as

BurnsCytokine Release SyndromeChild, PreschoolHumansMaleburn injurycytokine stormmassive burn injuryMeek micrograftingpediatric burn injury

Identifiers

PMID39820414
PMCPMC12344086

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.