Evidence map›Paper›PMID 39820353›Full record

ArticleNature communications2025

TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8

Kun Wei, Ruifeng Li, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Peng Wei, Wei Xu, Xinyi Guo and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Professor Emma Whitelaw, a pioneer of epigenetic inheritance.Frontiers in epigenetics and epigenomics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kun Wei *Institute for Immunology, Tsinghua University, Beijing, 100084, China.
Ruifeng Li *Institute for Immunology, Tsinghua University, Beijing, 100084, China.
Xiaohong ZhaoInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Bowen XieInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Tian XieInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Qinli SunInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Yongzhen ChenInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Peng WeiInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Wei XuInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Xinyi GuoInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Zixuan ZhaoInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Han FengInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Ling NiInstitute for Immunology, Tsinghua University, Beijing, 100084, China.
Chen DongShanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine- Affiliated Renji Hospital, Shanghai, 200127, China. dongchen@westlake.edu.cn.ORCID http://orcid.org/0000-0002-0084-9130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8

Indexed as

CD8-Positive T-LymphocytesChromatinLymphocyte ActivationTripartite Motif-Containing Protein 28AnimalsCCCTC-Binding FactorCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsInterleukin-2MiceMice, Inbred C57BLMice, KnockoutRNA Polymerase IITranscription, GeneticCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCtcf protein, mouseInterleukin-2RNA Polymerase IITrim28 protein, mouseTripartite Motif-Containing Protein 28

Identifiers

PMID39820353
PMCPMC11739657

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.