Evidence map›Paper›PMID 39820009›Full record

ArticleScientific reports2025

Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells.

Hanan R H Mohamed, Basma A Mohamed, George M Hakeem, Shahd H Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanan R H MohamedDepartment of Zoology, Faculty of Science, Cairo University, Giza, Egypt. hananeeyra@cu.edu.eg.
Basma A MohamedFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
George M HakeemFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Shahd H ElnawasaniFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Maria NagyFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Rawan EssamFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Ayman DiabFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.
Gehan SafwatFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), 6th of October City, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, the most aggressive and lethal form of skin cancer, with minimized systemic toxicity. However, the therapeutic efficacy of cobalt oxide nanoparticles (Co

Indexed as

ApoptosisCobaltMelanomaMetal NanoparticlesMitochondriaNanoparticlesOxidesReactive Oxygen SpeciesTumor Suppressor Protein p53Cell Line, TumorCell SurvivalDNA DamageHumansMembrane Potential, MitochondrialCobaltcobalt oxideOxidesReactive Oxygen SpeciesTumor Suppressor Protein p53Co3O4NPsMelanoma A-375 cellsMitochondrial dysfunctionOxidative DNA damagep53 independent apoptosis

Identifiers

PMID39820009
PMCPMC11739696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.