Evidence map›Paper›PMID 39819837›Full record

ArticleeLife2025

Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers.

Svanhild Nornes, Susann Bruche, Niharika Adak, Ian R McCracken, Sarah De Val

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. medRxiv : the preprint server for health sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Svanhild NornesInstitute of Developmental and Regenerative Medicine, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-5301-5252
Susann BrucheInstitute of Developmental and Regenerative Medicine, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-5814-7166
Niharika AdakInstitute of Developmental and Regenerative Medicine, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom.
Ian R McCrackenInstitute of Developmental and Regenerative Medicine, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom.
Sarah De ValInstitute of Developmental and Regenerative Medicine, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-2566-2348

Funding

British Heart Foundation FS/17/35/32929British Heart Foundation FS/1735/32929British Heart Foundation FS/IPBSRF/23/27085British Heart Foundation FS/SBSRF/22/31037British Heart Foundation RE/18/3/34214Fondation Leducq 18CVD03
6 · The paper itself

Abstract

The establishment and growth of the arterial endothelium require the coordinated expression of numerous genes. However, regulation of this process is not yet fully understood. Here, we combined in silico analysis with transgenic mice and zebrafish models to characterize arterial-specific enhancers associated with eight key arterial identity genes (

Indexed as

ArteriesEnhancer Elements, GeneticGene Expression RegulationTranscription FactorsTranscription, GeneticAnimalsGene Expression Regulation, DevelopmentalKruppel-Like Factor 4MiceMice, TransgenicZebrafishKlf4 protein, mouseKruppel-Like Factor 4Transcription Factorsarterial enhancerarterial gene transcriptionarteriovenous differentiationdevelopmental biologygeneticsgenomicsmouseSOXF transcription factorstranscriptional regulationvascular developmentzebrafish

Identifiers

PMID39819837
PMCPMC11896612

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.