Evidence map›Paper›PMID 39819737›Full record

ArticleEuropean journal of medical research2025

Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease.

Karsten Lürken, Anna Meinecke, Luis A Manthey, Anne Cossmann, Metodi V Stankov, Frank Klawonn, Anna Zychlinsky Scharff, Sandra Steffens, Alexandra Dopfer-Jablonka, Frank Müller and 2 more

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In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Karsten LürkenDialysis Centre Eickenhof, Langenhagen, Germany.
Anna MeineckeDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Luis A MantheyDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Anne CossmannDialysis Centre Eickenhof, Langenhagen, Germany.
Metodi V StankovDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Frank KlawonnInstitute of Information Engineering, Ostfalia University of Applied Sciences, Wolfenbüttel, Germany.
Anna Zychlinsky ScharffDepartment of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany.
Sandra SteffensDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Alexandra Dopfer-JablonkaDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Frank MüllerDepartment of General Practice, University Medical Center Göttingen, Göttingen, Germany.
Georg M N BehrensDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
Christine HappleDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany. Happle.christine@mh-hannover.de.

Funding

Deutsche Forschungsgemeinschaft Excellence Cluster Resist JRG fundingEuropean Regional Development Fund ZW7-85151373European Social Fund ZAM5-87006761Niedersächsisches Ministerium für Wissenschaft und Kultur 14-76103-184
6 · The paper itself

Abstract

backgroundPatients with end stage renal disease (ESRD) undergoing hemodialysis are at increased risk for infection and impaired vaccination responses. We analyzed overlap and influencing factors of vaccination responses against severe acute respiratory syndrome corona virus disease 2 (SARS-CoV-2) and Hepatitis B virus (HBV).

methodsSARS-CoV-2 and HBV vaccination response was assessed in a cohort of German ESRD hemodialysis patients. Anti-HBs- and SARS-CoV-2 anti-S-IgG were analyzed by ELISA. Demographic and clinical data were extracted from clinical files.

resultsSixty-four patients with complete information on HBV and SARS-CoV-2 vaccination responses were included. More than one-third (35.4%) of non-responders upon HBV vaccination were identified. Unresponsiveness after HBV and poor response after SARS-CoV-2 vaccination showed strong overlap, and overall, 70.3% of patients were classified into concordant HBV/SARS vaccination response groups. HBV vaccination non-responsiveness, but not poor SARS-CoV-2 post-vaccination immunity was associated with obesity, while poor SARS-CoV-2 vaccination responses were associated increased age.

conclusionOur findings confirm previous reports on impaired vaccination response in hemodialysis patients and show that post-vaccination humoral responses against SARS-CoV-2 and HBV display strong overlap in this vulnerable patient group. These results may help to adapt vaccination strategies in this highly vulnerable population.

trial registrationGerman Clinical Trial Registry, DRKS00021152.

Indexed as

COVID-19COVID-19 VaccinesHepatitis BHepatitis B VaccinesKidney Failure, ChronicRenal DialysisSARS-CoV-2AdultAgedFemaleGermanyHepatitis B virusHumansMaleMiddle AgedVaccinationCOVID-19 VaccinesHepatitis B VaccinesHBVHemodialysisSARS-CoV-2Vaccination response

Identifiers

PMID39819737
PMCPMC11736940

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.