Evidence map›Paper›PMID 39819729›Full record

ReviewNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

Strategies for long-acting drug design.

Muqi Huang, Zheng Cai, Shuwen Liu

Abstract readReview
In one paragraph

Review in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muqi HuangSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Zheng CaiSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Shuwen LiuSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Funding

National Natural Science Foundation of China 82130101 and 82173755
6 · The paper itself

Abstract

With advances of drug design and preparation technology, the development of long-acting drugs has become an important research focus in precision medicine and chronic disease management. These drugs are designed to improve the patients' compliance and quality of life by achieving prolonged maintenance of an effective drug concentration in the body with a reduced dosing frequency. Small molecule drugs, monoclonal antibodies and nucleic acid drugs all have their own difficulties in achieving long actions, which can be especially challenging for the latter two because of their structural complexity. This review provides an overview of the strategies for designing long-acting small molecule drugs, monoclonal antibodies, and nucleic acid drugs.

Indexed as

Antibodies, MonoclonalDrug DesignDelayed-Action PreparationsHumansNucleic AcidsPrecision MedicineAntibodies, MonoclonalDelayed-Action PreparationsNucleic Acidsdrug designlong-acting drugsmonoclonal antibodiesnucleic acid drugssmall molecule drugs

Identifiers

PMID39819729
PMCPMC11744288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.