Evidence map›Paper›PMID 39819685›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [

Karla M Ramos-Torres, Sara Conti, Yu-Peng Zhou, Amal Tiss, Celine Caravagna, Kazue Takahashi, Miao He, Moses Q Wilks, Sophie Eckl, Yang Sun and 5 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. First evaluation in multiple sclerosis using PET tracer [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Synthesis of KBioorganic & medicinal chemistry letters · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Karla M Ramos-TorresDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Sara ContiF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Yu-Peng ZhouDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Amal TissDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Celine CaravagnaF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Kazue TakahashiDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Miao HeF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Moses Q WilksDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Sophie EcklF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Yang SunDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Jason BiundoF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Kuang GongDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; and.
Clas LinnmanDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts.
Pedro BrugarolasDepartment of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; pbrugarolas@mgh.harvard.edu.

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Marc David Normandin · 2017 to 2026
$14.8M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
TissueCyte 1600FC Whole Mount Tissue ScannerS10OD026866 · OD · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2019
$612k
Development of next generation of α2δ-1 PET tracers for neuroimagingK99EB033407 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, YU-PENG · 2022 to 2023
$182k
NIBIB NIH HHS K99 EB033407NIBIB NIH HHS P41 EB022544NICHD NIH HHS P50 HD105351NIH HHS S10 OD026866NINDS NIH HHS R01 NS114066
6 · The paper itself

Abstract

Spinal cord injuries (SCIs) often lead to lifelong disability. Among the various types of injuries, incomplete and discomplete injuries, where some axons remain intact, offer potential for recovery. However, demyelination of these spared axons can worsen disability. Demyelination is a reversible phenomenon, and drugs such as 4-aminopyridine (4AP), which target K

Indexed as

AminopyridinesAxonsDemyelinating DiseasesPositron-Emission TomographySpinal Cord InjuriesAnimalsFemaleFluorine RadioisotopesHumansMaleRadioactive TracersRadiopharmaceuticalsRatsRats, Sprague-DawleyAminopyridinesFluorine RadioisotopesRadioactive TracersRadiopharmaceuticals[18F]3F4APdemyelinationPETspinal cord injurytranslational study

Identifiers

PMID39819685
PMCPMC11800733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.