Evidence map›Paper›PMID 39819530›Full record

ArticleCurrent drug delivery2026

Soluplus Stabilized Amorphous Dispersions for Enhanced Oral Absorption of Felodipine.

Shujuan Zhang, Subing Xiong, Ying Gong, Liangliang Wang, Dayun Huang

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Article in Current drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shujuan ZhangDepartment of Biopharmaceutical, Lishui University, 1 Xueyuan Road, Lishui, 323000, China.
Subing XiongCollege of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310032, China.
Ying GongDepartment of Pharmacology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310003, Zhejiang, China.
Liangliang WangDepartment of Biopharmaceutical, Lishui University, 1 Xueyuan Road, Lishui, 323000, China.
Dayun HuangDepartment of Biopharmaceutical, Lishui University, 1 Xueyuan Road, Lishui, 323000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOvercoming the poor aqueous solubility of small-molecule drugs is a major challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium channel blocker, is a poorly water-soluble drug.

objectivesThe study aimed to explore the potential applications of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) stabilized amorphous dispersions for augmenting the oral delivery of poorly water-soluble drugs.

methodsSoluplus-stabilized amorphous FLDP (FLDP-SSAs) was prepared using a two-phase mixing method. The samples were analyzed for their microscopic and macroscopic behavior using polarized light microscopy (PLM), differential scanning calorimetry (DSC), molecular simulation, and

resultsThe maximum drug-to-Soluplus mass ratio of FLDP-SSAs was 50:50, with a drug concentration of 8.0 mg/mL. They exhibited an amorphous nature, as confirmed by PLM and DSC. FLDPSSAs generated nanoparticles with a particle size of approximately 50 nm during

conclusionFLDP-SSAs could stabilize FLDP in an amorphous state and serve as drug carriers to enhance oral absorption.

Indexed as

Calcium Channel BlockersFelodipinePolyethylene GlycolsPolyvinylsAdministration, OralAnimalsDrug CarriersDrug LiberationMaleNanoparticlesParticle SizeRatsRats, Sprague-DawleySolubilityCalcium Channel BlockersDrug CarriersFelodipinePolyethylene Glycolspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsamorphous dispersionsFelodipinenanoparticleoral absorptionpharmacokineticssoluplus

Identifiers

PMID39819530

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