Evidence map›Paper›PMID 39819529›Full record

ArticleCurrent pharmaceutical biotechnology2026

A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential.

Alba Grifoni, John Sidney, Daniela Weiskopf, Richard H Scheuermann, Alessandro Sette

Abstract read
In one paragraph

Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Decoding the human CD4Cell reports. Medicine · 2026
    Article
  2. Comprehensive mapping of human CD4Cell reports. Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alba GrifoniCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.
John SidneyCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.
Daniela WeiskopfCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.
Richard H ScheuermannJ. Craig Venter Institute, La Jolla, CA, 92037, USA.
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.

Funding

BIOINFORMATICS RESOURCE CENTERS FOR INFECTIOUS DISEASES: SARS-CoV-2 ACTIVITIES75N93019C00076 · NIAID · UNIVERSITY OF CHICAGO · PI STEVENS, RICK · 2019 to 2023
$32.6M
The Development and Evaluation of Pan-Coronavirus VaccinesP01AI168347 · NIAID · WASHINGTON UNIVERSITY · PI Michael S Diamond · 2022 to 2026
$15.9M
Large Scale T Cell Epitope Discovery:Global identification of epitopes derived from Zika (ZIKV), Chikungunya (CHIKV) viruses following natural infection and vaccination75N93019C00065 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI MITCHELL, MAYA · 2019 to 2023
$7.3M
HHS P01 AI168347, 75N9301900065, HHS75N93019C00076NIAID NIH HHS 75N93019C00065NIAID NIH HHS 75N93019C00076NIAID NIH HHS P01 AI168347
6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has highlighted the need for society, as a whole, to be prepared against potential pandemics caused by a variety of different viral families of concern. Here, we describe a roadmap towards the identification and validation of conserved T cell epitope regions from Viral Families of Pandemic Potential (VFPP). For each viral family, we select a prototype virus, the sequence of which could be utilized in epitope identification screens. Examples of viral families considered and their respective prototypes (species/ subspecies) are

Indexed as

Epitopes, T-LymphocyteVirusesAnimalsCOVID-19HumansPandemicsSARS-CoV-2Viral VaccinesEpitopes, T-LymphocyteViral Vaccinescellular immunologyimmunitypandemicpeptidesT cell epitopesviral pathogens

Identifiers

PMID39819529
PMCPMC12892923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.