Evidence map›Paper›PMID 39819386›Full record

ArticleParticle and fibre toxicology2025

Pro-inflammatory effects of inhaled Great Salt Lake dust particles.

Jacob M Cowley, Cassandra E Deering-Rice, John G Lamb, Erin G Romero, Marysol Almestica-Roberts, Samantha N Serna, Lili Sun, Kerry E Kelly, Ross T Whitaker, Jenna Cheminant and 2 more

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. CYP1B1 modulates stress and repair pathways in airway cells challenged by wood smoke particles.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  4. Article
  5. Air pollution and alveolar health.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jacob M CowleyDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Cassandra E Deering-RiceDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
John G LambDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Erin G RomeroDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Marysol Almestica-RobertsDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Samantha N SernaDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Lili SunDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Kerry E KellyDepartment of Chemical Engineering, University of Utah, Salt Lake City, UT, 84112, USA.
Ross T WhitakerDepartment of Computer Science, University of Utah, Salt Lake City, UT, 84112, USA.
Jenna CheminantDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Alessandro VenosaDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA.
Christopher A ReillyDepartment of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, 30 S. 2000 E., Room 201 Skaggs Hall, Salt Lake City, UT, 84112, USA. Chris.Reilly@pharm.utah.edu.

Funding

TRP Channels and Air PollutionR01ES017431 · NIEHS · UNIVERSITY OF UTAH · PI REILLY, CHRISTOPHER A · 2009 to 2024
$5.3M
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary FibrosisR01ES032553 · NIEHS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI VENOSA, ALESSANDRO · 2021 to 2025
$2.1M
Margolis Foundation Collaborative Catalyst AwardNIEHS NIH HHS ES017431NIEHS NIH HHS ES032553NIEHS NIH HHS R01 ES017431NIEHS NIH HHS R01 ES032553
6 · The paper itself

Abstract

backgroundClimate change and human activities have caused the drying of marine environments around the world. An example is the Great Salt Lake in Utah, USA which is at a near record low water level. Adverse health effects have been associated with exposure to windblown dust originating from dried lakebed sediments, but mechanistic studies evaluating the health effects of these dusts are limited.

resultsMonitoring data and images highlight the impact of local crustal and Great Salt Lake sediment dusts on the Salt Lake Valley/Wasatch front airshed. Great Salt Lake sediment and derived PM

conclusionsDust from the GSL playa and similar dried lakebeds may affect human respiratory health via activation of TRPV1, TRPV3, TLR4, and oxidative stress.

Indexed as

Air PollutantsDustInhalation ExposureLakesParticulate MatterAnimalsBronchoalveolar Lavage FluidCell LineCytokinesEnvironmental MonitoringGeologic SedimentsHumansLungMaleMiceMice, Inbred C57BLAir PollutantsCytokinesDustParticulate MatterClimate changeDustGreat Salt LakeLipopolysaccharidesParticulate pollutionPulmonary inflammationSaline LakeSalton SeaToll-like receptor-4Transient receptor potential (TRP) channelTransition metal

Identifiers

PMID39819386
PMCPMC11737234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.