Evidence map›Paper›PMID 39819243›Full record

ArticleBioanalysis2025

Measuring HSD17β13 protein turnover in mouse liver with D

Yifan Shi, Amanda Del Rosario, Sheng-Ping Wang, Lijuan Kang, Haiying Liu, Brian Rady, Wenying Jian

Abstract read
In one paragraph

Article in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yifan ShiJanssen Research & Development, Spring House, PA, USA.ORCID 0000-0002-1164-2469
Amanda Del RosarioJanssen Research & Development, Spring House, PA, USA.
Sheng-Ping WangJanssen Research & Development, Spring House, PA, USA.
Lijuan KangJanssen Research & Development, Spring House, PA, USA.
Haiying LiuJanssen Research & Development, Spring House, PA, USA.
Brian RadyJanssen Research & Development, Spring House, PA, USA.
Wenying JianJanssen Research & Development, Spring House, PA, USA.ORCID 0000-0002-8731-981X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic labeling with heavy water (D

methodsA workflow that coupled immunocapture and LC-high-resolution MS to determine the synthesis rate of HSD17β13 protein in mouse liver was presented. Deuterium labeling of tryptic peptides was analyzed, and data were fitted into an exponential rise equation. RESULTS &

conclusionHSD17β13 protein t

Indexed as

17-Hydroxysteroid DehydrogenasesDeuterium OxideLiverMass SpectrometryAnimalsChromatography, LiquidLiquid Chromatography-Mass SpectrometryMaleMiceTandem Mass Spectrometry17-Hydroxysteroid DehydrogenasesDeuterium Oxideheavy waterhigh resolution mass spectrometryHSD17β13immunocaptureisotopesLC-MSmetabolic labelingProtein turnover

Identifiers

PMID39819243
PMCPMC11853646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.