ArticleNeurology2025
Prevalence of Fatigue and Associations With Depression and Cognitive Impairment in Patients With CADASIL.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cerebral small vessel disease: pearls and pitfalls from unexplored risk factors to treatment.Arquivos de neuro-psiquiatria · 2026Review
- Differentiation between depressive disorder and insomnia disorder with depressive symptoms across age groups using machine learning.Frontiers in psychiatry · 2026Article
- Defining patient-reported outcomes and priorities for clinical trials in CADASIL through an international survey.Cerebral circulation - cognition and behavior · 2026Article
- Observational
- Cognitive Functioning in Toxic Oil Syndrome Survivors: A Case-Control Study Four Decades After the Epidemic.Journal of clinical medicine · 2025Article
- Frontal-subcortical dysfunction in toxic oil syndrome: a proof-of-concept eye-tracking and cognitive study four decades after exposure.Frontiers in neuroscience · 2025Article
- Prevalence and Correlates of Depression and Anxiety Among Women with HPV-Related Cervical Disease: A Hospital-Based Cross-Sectional Study in Shenzhen, China.International journal of women's health · 2025Article
- Comment on "Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities: A prospective cohort study".Cerebral circulation - cognition and behavior · 2025Article
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5 authors.
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Abstract
BACKGROUND AND
objectivesFatigue is a common and disabling symptom in cerebrovascular disease and has been associated with white matter damage, but the underlying disease mechanisms are poorly understood. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common genetic form of stroke and causes a cerebral small vessel disease arteriopathy with white matter ischemia. We determined the prevalence of fatigue in CADASIL, the factors associated with it, and its relationship with both depression and cognitive impairment.
methodsProspectively recruited genetically confirmed patients with CADASIL were assessed using the Fatigue Severity Scale. The prevalence of fatigue in CADASIL was compared with that of healthy controls from the community. We determined associations between fatigue and clinical features, cardiovascular risk factors, MRI parameters, cognition, and depression. Cognition was measured using the Brief Memory and Executive Test (BMET) and depression using the Geriatric Depression Scale (GDS). Mediation and path analyses were performed to determine relationships between fatigue, depression, and cognitive impairment.
resultsOne hundred seventy-four patients with CADASIL (mean age [SD] of 51.3 [12.30] years, 59.66% female) and 50 healthy controls were included in the analysis (mean age [SD] of 51.42 [12.58] years, 38.0% female). Fatigue was present in 51.7% of patients with CADASIL and was almost 5 times more common than in controls (OR: 4.99, 95% CI [2.28-10.95], DISCUSSION: Fatigue was present in over half of the patients with CADASIL. Depression and cognition were the main predictors of fatigue, and all 3 symptoms were frequently comorbid. The relationship between depression and fatigue was the strongest and was bidirectional. This suggests targeting depressive symptoms may have benefit in fatigue management.
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