Evidence map›Paper›PMID 39819040›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Oxidative stress suppresses internal carotid artery dilation to hypercapnia in healthy older adults.

Kaitlin A Freeberg, Narissa P McCarty, Michel Chonchol, Douglas R Seals, Daniel H Craighead

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Sex Differences in Dementia and Mild Cognitive Impairment in Nondialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  3. Physiological responses to mask-associated COFrontiers in public health · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaitlin A FreebergDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.ORCID 0000-0003-4458-5103
Narissa P McCartyDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.ORCID 0000-0002-2391-9824
Daniel H CraigheadDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, United States.ORCID 0000-0002-8744-5349

Funding

Inspiratory muscle strength training for lowering blood pressure and improving endothelial function in postmenopausal women: comparison with "standard of care" aerobic exerciseR01AG071506 · NIA · UNIVERSITY OF COLORADO · PI DOUGLAS R SEALS · 2021 to 2026
$3.3M
Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive functionK01HL153326 · NHLBI · UNIVERSITY OF MINNESOTA · PI CRAIGHEAD, DANIEL HARRISON · 2020 to 2024
$899k
Nicotinamide Riboside Supplementation for Decreasing Inflammation in Middle-Aged and Older AdultsF31HL154782 · NHLBI · UNIVERSITY OF COLORADO · PI FREEBERG, KAITLIN · 2020 to 2022
$115k
HHS | National Institutes of Health (NIH) F31HL154782HHS | National Institutes of Health (NIH) K01HL153326HHS | National Institutes of Health (NIH) R01AG071506NHLBI NIH HHS F31 HL154782NHLBI NIH HHS K01 HL153326NIA NIH HHS R01 AG071506
6 · The paper itself

Abstract

Cerebrovascular disease and dementia risk increases with age, and lifetime risk is greater in women. Cerebrovascular dysfunction likely precedes cerebrovascular disease and dementia but the mechanisms are incompletely understood. We hypothesized that oxidative stress mediates cerebrovascular dysfunction with human aging. Internal carotid artery dilation (ICA

Indexed as

Carotid Artery, InternalHypercapniaOxidative StressVasodilationAdultAgedAgingAscorbic AcidCerebrovascular CirculationFemaleHumansMaleMiddle AgedMiddle Cerebral ArteryYoung AdultAscorbic Acidascorbic acidcerebrovascular reactivityreactive oxygen speciesvitamin C

Identifiers

PMID39819040
PMCPMC12167614

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.