Evidence map›Paper›PMID 39818965›Full record

ReviewJournal of virology2025

Insights into pathologic mechanisms occurring during serious adverse events following live zoster vaccination.

Peter G E Kennedy, Charles Grose

Abstract readReview
In one paragraph

Review in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter G E Kennedy1School of Psychology and Neuroscience, College of Medical, Veterinary & Life Sciences, Garscube Campus, University of Glasgow, Glasgow, Scotland, United Kingdom.
Charles GroseDivision of Infectious Diseases, Virology Laboratory, Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-6884-6668

Funding

Wild-type allele found in varicella vaccine virus during severe herpes zosterR21AI153817 · NIAID · UNIVERSITY OF IOWA · PI GROSE, CHARLES F. · 2020 to 2021
$420k
NIAID NIH HHS R21 AI153817
6 · The paper itself

Abstract

An effective live zoster vaccine has been widely used around the world. Although no deaths occurred in the original large clinical trial, we analyzed 10 serious adverse events, including six deaths that have subsequently occurred in four countries. The goal is to define the viral pathogenesis of these unexpected adverse events secondary to a viremia with dissemination of the vaccine virus. We also propose a new hypothesis for acute retinal necrosis that occurs post-immunization.

Indexed as

Herpesvirus 3, HumanHerpes ZosterHerpes Zoster VaccineRetinal Necrosis Syndrome, AcuteVaccinationFemaleHumansMaleVaccines, AttenuatedViremiaHerpes Zoster VaccineVaccines, Attenuatedacute retinal necrosispathogenesissingle nucleotide polymorphismsvaricella vaccinevaricella-zoster virusVZV ORF0

Identifiers

PMID39818965
PMCPMC11852805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.